Suppression of immunologic function and degeneration of lymphoid organs in cyclophosphamide-treated turkeys.

A. K. Elmubarak, J. M. Sharma, L. F. Lee, V. L. Sanger

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Neonatal administration of 8 to 20 mg of cyclophosphamide (CY) in turkey poults resulted in a marked alteration in the morphologic features of all major lymphoid organs. Cyclophosphamide induced severe deficiency in antibody response to multiple injections of Brucella abortus and sheep RBC and in vitro proliferative response of peripheral blood leukocytes to concanavalin A. The morphologic regeneration of thymus and of thymus-dependent areas was marked in all major lymphoid organs by posttreatment day 15. This regeneration preceded functional recovery of the mitogenic response of peripheral blood leukocytes. The regeneration of the bursa and bursa-dependent areas in other lymphoid organs was minimal through posttreatment day 27. Thus, CY may be used effectively in turkeys as an immunosuppressive reagent.

Original languageEnglish (US)
Pages (from-to)2122-2128
Number of pages7
JournalAmerican Journal of Veterinary Research
Volume42
Issue number12
StatePublished - Dec 1981
Externally publishedYes

Fingerprint

cyclophosphamide
Cyclophosphamide
Regeneration
Thymus Gland
leukocytes
Leukocytes
Brucella abortus
immunosuppressive agents
poults
Brucella melitensis biovar Abortus
blood
Immunosuppressive Agents
concanavalin A
Concanavalin A
Antibody Formation
Sheep
erythrocytes
injection
sheep
Injections

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Suppression of immunologic function and degeneration of lymphoid organs in cyclophosphamide-treated turkeys. / Elmubarak, A. K.; Sharma, J. M.; Lee, L. F.; Sanger, V. L.

In: American Journal of Veterinary Research, Vol. 42, No. 12, 12.1981, p. 2122-2128.

Research output: Contribution to journalArticle

Elmubarak, A. K. ; Sharma, J. M. ; Lee, L. F. ; Sanger, V. L. / Suppression of immunologic function and degeneration of lymphoid organs in cyclophosphamide-treated turkeys. In: American Journal of Veterinary Research. 1981 ; Vol. 42, No. 12. pp. 2122-2128.
@article{56d8f29df2ad4ce29c36c0667c660365,
title = "Suppression of immunologic function and degeneration of lymphoid organs in cyclophosphamide-treated turkeys.",
abstract = "Neonatal administration of 8 to 20 mg of cyclophosphamide (CY) in turkey poults resulted in a marked alteration in the morphologic features of all major lymphoid organs. Cyclophosphamide induced severe deficiency in antibody response to multiple injections of Brucella abortus and sheep RBC and in vitro proliferative response of peripheral blood leukocytes to concanavalin A. The morphologic regeneration of thymus and of thymus-dependent areas was marked in all major lymphoid organs by posttreatment day 15. This regeneration preceded functional recovery of the mitogenic response of peripheral blood leukocytes. The regeneration of the bursa and bursa-dependent areas in other lymphoid organs was minimal through posttreatment day 27. Thus, CY may be used effectively in turkeys as an immunosuppressive reagent.",
author = "Elmubarak, {A. K.} and Sharma, {J. M.} and Lee, {L. F.} and Sanger, {V. L.}",
year = "1981",
month = "12",
language = "English (US)",
volume = "42",
pages = "2122--2128",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "12",

}

TY - JOUR

T1 - Suppression of immunologic function and degeneration of lymphoid organs in cyclophosphamide-treated turkeys.

AU - Elmubarak, A. K.

AU - Sharma, J. M.

AU - Lee, L. F.

AU - Sanger, V. L.

PY - 1981/12

Y1 - 1981/12

N2 - Neonatal administration of 8 to 20 mg of cyclophosphamide (CY) in turkey poults resulted in a marked alteration in the morphologic features of all major lymphoid organs. Cyclophosphamide induced severe deficiency in antibody response to multiple injections of Brucella abortus and sheep RBC and in vitro proliferative response of peripheral blood leukocytes to concanavalin A. The morphologic regeneration of thymus and of thymus-dependent areas was marked in all major lymphoid organs by posttreatment day 15. This regeneration preceded functional recovery of the mitogenic response of peripheral blood leukocytes. The regeneration of the bursa and bursa-dependent areas in other lymphoid organs was minimal through posttreatment day 27. Thus, CY may be used effectively in turkeys as an immunosuppressive reagent.

AB - Neonatal administration of 8 to 20 mg of cyclophosphamide (CY) in turkey poults resulted in a marked alteration in the morphologic features of all major lymphoid organs. Cyclophosphamide induced severe deficiency in antibody response to multiple injections of Brucella abortus and sheep RBC and in vitro proliferative response of peripheral blood leukocytes to concanavalin A. The morphologic regeneration of thymus and of thymus-dependent areas was marked in all major lymphoid organs by posttreatment day 15. This regeneration preceded functional recovery of the mitogenic response of peripheral blood leukocytes. The regeneration of the bursa and bursa-dependent areas in other lymphoid organs was minimal through posttreatment day 27. Thus, CY may be used effectively in turkeys as an immunosuppressive reagent.

UR - http://www.scopus.com/inward/record.url?scp=0019763254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019763254&partnerID=8YFLogxK

M3 - Article

C2 - 6803620

AN - SCOPUS:0019763254

VL - 42

SP - 2122

EP - 2128

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 12

ER -