Abstract
Three experiments investigated effects of jejunal lipid infusions given on 4 or 21 consecutive days in adult, male Sprague-Dawley rats. In experiment 1, 7-h infusions of linoleic or oleic acid (0.2 ml/h for 7 h; total load = 11.5 kcal) on 4 consecutive days reduced total intake (ad libitum consumption of the liquid diet Boost, Mead Johnson, plus load) by ~15% and decreased weight gain compared with 4-day tests with saline administration. In experiment 2, linoleic acid at 0.1 ml/h for 7 h (5.7 kcal) was ineffective, whereas the same load delivered in 3.5 h produced effects similar in magnitude to those in the first experiment. In experiment 3, jejunal infusions of linoleic acid (0.2 ml/h for 7 h) on 21 consecutive days reduced mean total intake by 16%, body weight by 10%, and carcass fat by 48% compared with controls receiving saline. The net decrease in caloric intake may reflect the combined activation of pre- and postabsorptive mechanisms, and it suggests a possible treatment for obesity.
Original language | English (US) |
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Pages (from-to) | R604-R610 |
Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
Volume | 278 |
Issue number | 3 47-3 |
DOIs | |
State | Published - Mar 2000 |
Externally published | Yes |
Keywords
- Linoleic acid
- Oleic acid
- Satiety
- Small intestine
ASJC Scopus subject areas
- Physiology
- Physiology (medical)