Supervised, vigorous intensity exercise intervention for depressed female smokers: A pilot study

Christi A. Patten, Carrie A. Bronars, Kristin S Vickers Douglas, Michael H. Ussher, James A. Levine, Susannah J. Tye, Christine A. Hughes, Tabetha A. Brockman, Paul A. Decker, Ramona S. DeJesus, Mark D. Williams, Thomas P. Olson, Matthew M. Clark, Angela M. Dieterich

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Introduction: Few studies have evaluated exercise interventions for smokers with depression or other psychiatric comorbidities. This pilot study evaluated the potential role of supervised vigorous exercise as a smoking cessation intervention for depressed females. Methods: Thirty adult women with moderate-severe depressive symptoms were enrolled and randomly assigned to 12 weeks of thrice weekly, in person sessions of vigorous intensity supervised exercise at a YMCA setting (EX; n = 15) or health education (HE; n = 15). All participants received behavioral smoking cessation counseling and nicotine patch therapy. Assessments were done in person at baseline, at the end of 12 weeks of treatment, and at 6 months post-target quit date. Primary end points were exercise adherence (proportion of 36 sessions attended) and biochemically confirmed 7-day point prevalence abstinence at Week 12. Biomarkers of inflammation were explored for differences between treatment groups and between women who smoked and those abstinent at Week 12. Results: Treatment adherence was high for both groups (72% for EX and 66% for HE; p = .55). The Week 12 smoking abstinence rate was higher for EX than HE (11/15 [73%] vs. 5/15 [33%]; p = .028), but no significant differences emerged at 6-month follow-up. Interleukin-6 levels increased more for those smoking than women abstinent at Week 12 (p = .040). Conclusions: Vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. Innovative and cost-effective strategies to bolster long-term exercise adherence and smoking cessation need evaluation in this population. Inflammatory biomarkers could be examined in future research as mediators of treatment efficacy. Implications: This preliminary study found that vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. This research addressed an important gap in the field. Despite decades of research examining exercise interventions for smoking cessation, few studies were done among depressed smokers or those with comorbid psychiatric disorders. A novel finding was increases in levels of a pro-inflammatory biomarker observed among women who smoked at the end of the intervention compared to those who did not.

Original languageEnglish (US)
Pages (from-to)77-86
Number of pages10
JournalNicotine and Tobacco Research
Volume19
Issue number1
DOIs
StatePublished - 2017
Externally publishedYes

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Smoking Cessation
Exercise
Biomarkers
Psychiatry
Smoking
Depression
Tobacco Use Cessation Products
Therapeutics
Health Education
Research
Comorbidity
Counseling
Interleukin-6
Inflammation
Costs and Cost Analysis
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Patten, C. A., Bronars, C. A., Douglas, K. S. V., Ussher, M. H., Levine, J. A., Tye, S. J., ... Dieterich, A. M. (2017). Supervised, vigorous intensity exercise intervention for depressed female smokers: A pilot study. Nicotine and Tobacco Research, 19(1), 77-86. https://doi.org/10.1093/ntr/ntw208

Supervised, vigorous intensity exercise intervention for depressed female smokers : A pilot study. / Patten, Christi A.; Bronars, Carrie A.; Douglas, Kristin S Vickers; Ussher, Michael H.; Levine, James A.; Tye, Susannah J.; Hughes, Christine A.; Brockman, Tabetha A.; Decker, Paul A.; DeJesus, Ramona S.; Williams, Mark D.; Olson, Thomas P.; Clark, Matthew M.; Dieterich, Angela M.

In: Nicotine and Tobacco Research, Vol. 19, No. 1, 2017, p. 77-86.

Research output: Contribution to journalArticle

Patten, CA, Bronars, CA, Douglas, KSV, Ussher, MH, Levine, JA, Tye, SJ, Hughes, CA, Brockman, TA, Decker, PA, DeJesus, RS, Williams, MD, Olson, TP, Clark, MM & Dieterich, AM 2017, 'Supervised, vigorous intensity exercise intervention for depressed female smokers: A pilot study', Nicotine and Tobacco Research, vol. 19, no. 1, pp. 77-86. https://doi.org/10.1093/ntr/ntw208
Patten, Christi A. ; Bronars, Carrie A. ; Douglas, Kristin S Vickers ; Ussher, Michael H. ; Levine, James A. ; Tye, Susannah J. ; Hughes, Christine A. ; Brockman, Tabetha A. ; Decker, Paul A. ; DeJesus, Ramona S. ; Williams, Mark D. ; Olson, Thomas P. ; Clark, Matthew M. ; Dieterich, Angela M. / Supervised, vigorous intensity exercise intervention for depressed female smokers : A pilot study. In: Nicotine and Tobacco Research. 2017 ; Vol. 19, No. 1. pp. 77-86.
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abstract = "Introduction: Few studies have evaluated exercise interventions for smokers with depression or other psychiatric comorbidities. This pilot study evaluated the potential role of supervised vigorous exercise as a smoking cessation intervention for depressed females. Methods: Thirty adult women with moderate-severe depressive symptoms were enrolled and randomly assigned to 12 weeks of thrice weekly, in person sessions of vigorous intensity supervised exercise at a YMCA setting (EX; n = 15) or health education (HE; n = 15). All participants received behavioral smoking cessation counseling and nicotine patch therapy. Assessments were done in person at baseline, at the end of 12 weeks of treatment, and at 6 months post-target quit date. Primary end points were exercise adherence (proportion of 36 sessions attended) and biochemically confirmed 7-day point prevalence abstinence at Week 12. Biomarkers of inflammation were explored for differences between treatment groups and between women who smoked and those abstinent at Week 12. Results: Treatment adherence was high for both groups (72{\%} for EX and 66{\%} for HE; p = .55). The Week 12 smoking abstinence rate was higher for EX than HE (11/15 [73{\%}] vs. 5/15 [33{\%}]; p = .028), but no significant differences emerged at 6-month follow-up. Interleukin-6 levels increased more for those smoking than women abstinent at Week 12 (p = .040). Conclusions: Vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. Innovative and cost-effective strategies to bolster long-term exercise adherence and smoking cessation need evaluation in this population. Inflammatory biomarkers could be examined in future research as mediators of treatment efficacy. Implications: This preliminary study found that vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. This research addressed an important gap in the field. Despite decades of research examining exercise interventions for smoking cessation, few studies were done among depressed smokers or those with comorbid psychiatric disorders. A novel finding was increases in levels of a pro-inflammatory biomarker observed among women who smoked at the end of the intervention compared to those who did not.",
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T1 - Supervised, vigorous intensity exercise intervention for depressed female smokers

T2 - A pilot study

AU - Patten, Christi A.

AU - Bronars, Carrie A.

AU - Douglas, Kristin S Vickers

AU - Ussher, Michael H.

AU - Levine, James A.

AU - Tye, Susannah J.

AU - Hughes, Christine A.

AU - Brockman, Tabetha A.

AU - Decker, Paul A.

AU - DeJesus, Ramona S.

AU - Williams, Mark D.

AU - Olson, Thomas P.

AU - Clark, Matthew M.

AU - Dieterich, Angela M.

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N2 - Introduction: Few studies have evaluated exercise interventions for smokers with depression or other psychiatric comorbidities. This pilot study evaluated the potential role of supervised vigorous exercise as a smoking cessation intervention for depressed females. Methods: Thirty adult women with moderate-severe depressive symptoms were enrolled and randomly assigned to 12 weeks of thrice weekly, in person sessions of vigorous intensity supervised exercise at a YMCA setting (EX; n = 15) or health education (HE; n = 15). All participants received behavioral smoking cessation counseling and nicotine patch therapy. Assessments were done in person at baseline, at the end of 12 weeks of treatment, and at 6 months post-target quit date. Primary end points were exercise adherence (proportion of 36 sessions attended) and biochemically confirmed 7-day point prevalence abstinence at Week 12. Biomarkers of inflammation were explored for differences between treatment groups and between women who smoked and those abstinent at Week 12. Results: Treatment adherence was high for both groups (72% for EX and 66% for HE; p = .55). The Week 12 smoking abstinence rate was higher for EX than HE (11/15 [73%] vs. 5/15 [33%]; p = .028), but no significant differences emerged at 6-month follow-up. Interleukin-6 levels increased more for those smoking than women abstinent at Week 12 (p = .040). Conclusions: Vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. Innovative and cost-effective strategies to bolster long-term exercise adherence and smoking cessation need evaluation in this population. Inflammatory biomarkers could be examined in future research as mediators of treatment efficacy. Implications: This preliminary study found that vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. This research addressed an important gap in the field. Despite decades of research examining exercise interventions for smoking cessation, few studies were done among depressed smokers or those with comorbid psychiatric disorders. A novel finding was increases in levels of a pro-inflammatory biomarker observed among women who smoked at the end of the intervention compared to those who did not.

AB - Introduction: Few studies have evaluated exercise interventions for smokers with depression or other psychiatric comorbidities. This pilot study evaluated the potential role of supervised vigorous exercise as a smoking cessation intervention for depressed females. Methods: Thirty adult women with moderate-severe depressive symptoms were enrolled and randomly assigned to 12 weeks of thrice weekly, in person sessions of vigorous intensity supervised exercise at a YMCA setting (EX; n = 15) or health education (HE; n = 15). All participants received behavioral smoking cessation counseling and nicotine patch therapy. Assessments were done in person at baseline, at the end of 12 weeks of treatment, and at 6 months post-target quit date. Primary end points were exercise adherence (proportion of 36 sessions attended) and biochemically confirmed 7-day point prevalence abstinence at Week 12. Biomarkers of inflammation were explored for differences between treatment groups and between women who smoked and those abstinent at Week 12. Results: Treatment adherence was high for both groups (72% for EX and 66% for HE; p = .55). The Week 12 smoking abstinence rate was higher for EX than HE (11/15 [73%] vs. 5/15 [33%]; p = .028), but no significant differences emerged at 6-month follow-up. Interleukin-6 levels increased more for those smoking than women abstinent at Week 12 (p = .040). Conclusions: Vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. Innovative and cost-effective strategies to bolster long-term exercise adherence and smoking cessation need evaluation in this population. Inflammatory biomarkers could be examined in future research as mediators of treatment efficacy. Implications: This preliminary study found that vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. This research addressed an important gap in the field. Despite decades of research examining exercise interventions for smoking cessation, few studies were done among depressed smokers or those with comorbid psychiatric disorders. A novel finding was increases in levels of a pro-inflammatory biomarker observed among women who smoked at the end of the intervention compared to those who did not.

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