Abstract
This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.
| Original language | English (US) |
|---|---|
| Article number | 1473707 |
| Journal | Journal of Extracellular Vesicles |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2018 |
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Keywords
- Biomarkers
- cancer
- exosomes
- extracellular vesicles
- plasma
- serum
- urine
ASJC Scopus subject areas
- Histology
- Cell Biology
Cite this
Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. / Clayton, Aled; Buschmann, Dominik; Byrd, J. Brian; Carter, David R.F.; Cheng, Lesley; Compton, Carolyn; Daaboul, George; Devitt, Andrew; Falcon-Perez, Juan Manuel; Gardiner, Chris; Gustafson, Dakota; Harrison, Paul; Helmbrecht, Clemens; Hendrix, An; Hill, Andrew; Hoffman, Andrew; Jones, Jennifer C.; Kalluri, Raghu; Kang, Ji Yoon; Kirchner, Benedikt; Lässer, Cecilia; Lawson, Charlotte; Lenassi, Metka; Levin, Carina; Llorente, Alicia; Martens-Uzunova, Elena S.; Möller, Andreas; Musante, Luca; Ochiya, Takahiro; Pink, Ryan C.; Tahara, Hidetoshi; Wauben, Marca H.M.; Webber, Jason P.; Welsh, Joshua A.; Witwer, Kenneth W.; Yin, Hang; Nieuwland, Rienk.
In: Journal of Extracellular Vesicles, Vol. 7, No. 1, 1473707, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017
AU - Clayton, Aled
AU - Buschmann, Dominik
AU - Byrd, J. Brian
AU - Carter, David R.F.
AU - Cheng, Lesley
AU - Compton, Carolyn
AU - Daaboul, George
AU - Devitt, Andrew
AU - Falcon-Perez, Juan Manuel
AU - Gardiner, Chris
AU - Gustafson, Dakota
AU - Harrison, Paul
AU - Helmbrecht, Clemens
AU - Hendrix, An
AU - Hill, Andrew
AU - Hoffman, Andrew
AU - Jones, Jennifer C.
AU - Kalluri, Raghu
AU - Kang, Ji Yoon
AU - Kirchner, Benedikt
AU - Lässer, Cecilia
AU - Lawson, Charlotte
AU - Lenassi, Metka
AU - Levin, Carina
AU - Llorente, Alicia
AU - Martens-Uzunova, Elena S.
AU - Möller, Andreas
AU - Musante, Luca
AU - Ochiya, Takahiro
AU - Pink, Ryan C.
AU - Tahara, Hidetoshi
AU - Wauben, Marca H.M.
AU - Webber, Jason P.
AU - Welsh, Joshua A.
AU - Witwer, Kenneth W.
AU - Yin, Hang
AU - Nieuwland, Rienk
PY - 2018/1/1
Y1 - 2018/1/1
N2 - This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.
AB - This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.
KW - Biomarkers
KW - cancer
KW - exosomes
KW - extracellular vesicles
KW - plasma
KW - serum
KW - urine
UR - http://www.scopus.com/inward/record.url?scp=85047262302&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047262302&partnerID=8YFLogxK
U2 - 10.1080/20013078.2018.1473707
DO - 10.1080/20013078.2018.1473707
M3 - Article
VL - 7
JO - Journal of Extracellular Vesicles
JF - Journal of Extracellular Vesicles
SN - 2001-3078
IS - 1
M1 - 1473707
ER -