@article{957f115a2fc84cea98d3bce8826eb290,
title = "Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017",
abstract = "This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.",
keywords = "Biomarkers, cancer, exosomes, extracellular vesicles, plasma, serum, urine",
author = "Aled Clayton and Dominik Buschmann and Byrd, {J. Brian} and Carter, {David R.F.} and Lesley Cheng and Carolyn Compton and George Daaboul and Andrew Devitt and Falcon-Perez, {Juan Manuel} and Chris Gardiner and Dakota Gustafson and Paul Harrison and Clemens Helmbrecht and An Hendrix and Andrew Hill and Andrew Hoffman and Jones, {Jennifer C.} and Raghu Kalluri and Kang, {Ji Yoon} and Benedikt Kirchner and Cecilia L{\"a}sser and Charlotte Lawson and Metka Lenassi and Carina Levin and Alicia Llorente and Martens-Uzunova, {Elena S.} and Andreas M{\"o}ller and Luca Musante and Takahiro Ochiya and Pink, {Ryan C.} and Hidetoshi Tahara and Wauben, {Marca H.M.} and Webber, {Jason P.} and Welsh, {Joshua A.} and Witwer, {Kenneth W.} and Hang Yin and Rienk Nieuwland",
note = "Funding Information: The organisers thank all presenters, session chairpersons and round-table moderators for the content and discussions arising. We also thank all attendees for their valued, discursive contributions. The workshop was part funded from an Endeavour Award from the Life Science Research Network Wales, and from commercial sponsor contributions from Exosomics Siena, HansaBioMed Life Sciences (Lonza), Izon, NanoView Diagnostics and Particle Metrix. We are grateful to Dr Paul Harrison and Mrs Elizabeth Harrison, Birmingham University, for hosting the event. Funding Information: The workshop was part funded from an Endeavour Award from the Life Science Research Network Wales, and from commercial sponsor contributions from Exosomics Siena, HansaBioMed Life Sciences (Lonza), Izon, NanoView Diagnostics and Particle Metrix.",
year = "2018",
month = jan,
day = "1",
doi = "10.1080/20013078.2018.1473707",
language = "English (US)",
volume = "7",
journal = "Journal of Extracellular Vesicles",
issn = "2001-3078",
publisher = "Taylor and Francis Ltd.",
number = "1",
}