Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth

Christopher S. Williams, Angela P. Goldman, Hongmiao Sheng, Jason D. Morrow, Raymond N. DuBois

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animals with colorectal cancer. Another sulindac sulfoxide metabolite, sulindac sulfone, has been reported to have antitumor properties without inhibiting cyclooxygenase activity. Here we report the effect of sulindac sulfone treatment on the growth of colorectal carcinoma cells. We observed that sulindac sulfide or sulfone treatment of HCA-7 cells led to inhibition of prostaglandin E2 production. Both sulindac sulfide and sulfone inhibited HCA-7 and HCT-116 cell growth in vitro. Sulindac sulfone had no effect on the growth of either HCA-7 or HCT-116 xenografts, whereas the sulfide derivative inhibited HCA-7 growth in vivo. Both sulindac sulfide and sulfone inhibited colon carcinoma cell growth and prostaglandin production in vitro, but sulindac sulfone had no effect on the growth of colon cancer cell xenografts in nude mice.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalNeoplasia
Volume1
Issue number2
StatePublished - Jun 1 1999

Keywords

  • Chemoprevention
  • Colorectal cancer
  • Sulindac
  • Sulindac sulfide
  • Sulindac sulfone

ASJC Scopus subject areas

  • Cancer Research

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    Williams, C. S., Goldman, A. P., Sheng, H., Morrow, J. D., & DuBois, R. N. (1999). Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth. Neoplasia, 1(2), 170-176.