Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth

Christopher S. Williams, Angela P. Goldman, Hongmiao Sheng, Jason D. Morrow, Raymond N. DuBois

    Research output: Contribution to journalArticlepeer-review

    36 Scopus citations

    Abstract

    Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animals with colorectal cancer. Another sulindac sulfoxide metabolite, sulindac sulfone, has been reported to have antitumor properties without inhibiting cyclooxygenase activity. Here we report the effect of sulindac sulfone treatment on the growth of colorectal carcinoma cells. We observed that sulindac sulfide or sulfone treatment of HCA-7 cells led to inhibition of prostaglandin E2 production. Both sulindac sulfide and sulfone inhibited HCA-7 and HCT-116 cell growth in vitro. Sulindac sulfone had no effect on the growth of either HCA-7 or HCT-116 xenografts, whereas the sulfide derivative inhibited HCA-7 growth in vivo. Both sulindac sulfide and sulfone inhibited colon carcinoma cell growth and prostaglandin production in vitro, but sulindac sulfone had no effect on the growth of colon cancer cell xenografts in nude mice.

    Original languageEnglish (US)
    Pages (from-to)170-176
    Number of pages7
    JournalNeoplasia
    Volume1
    Issue number2
    DOIs
    StatePublished - Jun 1999

    Keywords

    • Chemoprevention
    • Colorectal cancer
    • Sulindac
    • Sulindac sulfide
    • Sulindac sulfone

    ASJC Scopus subject areas

    • Cancer Research

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