TY - JOUR
T1 - Sulfhydryl-reactive metals in autism
AU - Kern, Janet K.
AU - Grannemann, Bruce D.
AU - Trivedi, Madhukar H.
AU - Adams, James
N1 - Funding Information:
This research was funded by a grant from the Autism Research Institute. The authors acknowledge the help of the Autism Society of Collin County, Rainbow Connection Daycare, Storybook Daycare, Discovery Learning Center, First Steps Learning Center, and East Side Speech and Language Clinic.
PY - 2007/1
Y1 - 2007/1
N2 - This study examined the difference between sulfhydryl-reactive metals (mercury, lead, arsenic, and cadmium) in the hair of 45 children with autism (1-6 yr of age) as compared to 45 gender-, age-, and race-matched typical children. Hair samples were measured with inductively coupled mass spectrometry. Some studies, such as Holmes et al. (2003), suggested that children with autism may be poor detoxifiers relative to normally developing children. Metals that are not eliminated sequester in the brain. Our study found that arsenic, cadmium, and lead were significantly lower in the hair of children with autism than in matched controls. Mercury was in the same direction (lower in autism) following the same pattern, but did not achieve statistical significance. The evidence from our study supports the notion that children with autism may have trouble excreting these metals, resulting in a higher body burden that may contribute to symptoms of autism.
AB - This study examined the difference between sulfhydryl-reactive metals (mercury, lead, arsenic, and cadmium) in the hair of 45 children with autism (1-6 yr of age) as compared to 45 gender-, age-, and race-matched typical children. Hair samples were measured with inductively coupled mass spectrometry. Some studies, such as Holmes et al. (2003), suggested that children with autism may be poor detoxifiers relative to normally developing children. Metals that are not eliminated sequester in the brain. Our study found that arsenic, cadmium, and lead were significantly lower in the hair of children with autism than in matched controls. Mercury was in the same direction (lower in autism) following the same pattern, but did not achieve statistical significance. The evidence from our study supports the notion that children with autism may have trouble excreting these metals, resulting in a higher body burden that may contribute to symptoms of autism.
UR - http://www.scopus.com/inward/record.url?scp=33847413570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847413570&partnerID=8YFLogxK
U2 - 10.1080/15287390601188060
DO - 10.1080/15287390601188060
M3 - Article
C2 - 17365626
AN - SCOPUS:33847413570
SN - 1528-7394
VL - 70
SP - 715
EP - 721
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 8
ER -