Substantia nigra tangles are related to gait impairment in older persons

Julie A. Schneider, Jia Liang Li, Yan Li, Robert S. Wilson, Jeffrey H. Kordower, David A. Bennett

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

Objective: Parkinsonian signs, especially gait impairment, are common and associated with morbidity and mortality in older persons. Our objective was to test the hypothesis that substantia nigra neurofibrillary tangles (NFTs) are related to parkinsonian signs in older persons with and without dementia. Methods: We studied 86 deceased older Catholic clergy without idiopathic Parkinson's disease from the Religious Order Study, a longitudinal clinical-pathological study. Mean age at death was 85.3 years. Signs of gait disturbance, bradykinesia, rigidity, and tremor were assessed proximate to death using a modified Unified Parkinson's Disease Rating Scale. Forty-micrometer paraffin-embedded sections of substantia nigra were bleached before tau immunohistochemistry and the optical disector was used to count NFTs. We used multivariable linear regression to examine parkinsonian signs as a function of nigra NFTs, controlling for age, sex, education, and cortical NFTs. Results: Substantia nigra NFTs were present in 67 of 86 persons (77.9%). After controlling for age, sex, education, and cortical NFTs, nigra NFTs were related to gait impairment (p < 0.001), but not bradykinesia, rigidity, or tremor. Results were not confounded by dementia, Braak score, neuroleptic medication, cerebral infarcts, or Lewy bodies. Interpretation: NFTs in the substantia nigra are associated with gait impairment in older persons with and without dementia.

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalAnnals of Neurology
Volume59
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Substantia nigra tangles are related to gait impairment in older persons'. Together they form a unique fingerprint.

Cite this