Subjective and cardiovascular effects of cocaine during treatment with amantadine and baclofen in combination

Erin Rotheram-Fuller, Richard De La Garza, James J. Mahoney, Steve Shoptaw, Thomas F. Newton

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


This study assessed the subjective and cardiovascular effects of relevant doses of cocaine administration during steady-state treatment of the combination of amantadine and baclofen compared to placebo. Participants included 8 healthy, male, cocaine-dependent, non-treatment-seeking individuals (age = 36.6 ± 5.9; 75% African American, 25% Caucasian; using cocaine for an average of 15.3 ± 6.5 years). Data were collected prior to and following double-blind intravenous administration of 0 mg, 20 mg, and 40 mg of cocaine. Data were collected at baseline, following 5 days of treatment with placebo, and again following 5 days of treatment with a combination of amantadine 100 mg t.i.d. and baclofen 30 mg t.i.d. counterbalanced for order of medication and placebo in a cross-over design. Results showed no significant alterations to cardiovascular variables (heart rate, systolic and diastolic blood pressure) from treatment using combination medication or placebo in the presence of cocaine. Self-rated "desire" for cocaine was significantly lower during cocaine administrations while participants were receiving treatment with amantadine-baclofen compared to infusions while taking placebo medication, although there was no difference in the intensity of cocaine-induced euphoria, or reduction in the likelihood to use cocaine if given access. Study findings support the safety of the amantadine-baclofen combination treatment for cocaine dependence.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalPsychiatry Research
Issue number2-3
StatePublished - Aug 30 2007
Externally publishedYes


  • Amantadine
  • Baclofen
  • Cocaine
  • Pharmacotherapy
  • Phase I Clinical Trial

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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