Stunted by developing in hypoxia: Linking comparative and model organism studies

Jon Harrison, Alexander W. Shingleton, Viviane Callier

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Animals develop in atmospheric hypoxia in a wide range of habitats, and tissues may experience O<inf>2</inf> limitation of ATP production during postembryonic development if O<inf>2</inf> supply structures do not keep pace with growing O<inf>2</inf> demand during ontogeny. Most animal species are stunted by postembryonic development in hypoxia, showing reduced growth rates and size in moderate hypoxia (5-15 kPa Po<inf>2</inf>). In mammals, the critical Po<inf>2</inf> that limits resting metabolic rate also falls in this same moderate hypoxic range, so stunted growth may simply be due to hypoxic limits on ATP production. However, inmost invertebrates and at least some lower vertebrates, hypoxic stunting occurs at Po<inf>2</inf> values well above those that limit resting metabolism. Studies with diverse model organisms have identified multiple homologous O<inf>2</inf>-sensing signaling pathways that can inhibit feeding and growth during moderate hypoxia. Together, these comparative and model organism-based studies suggest that hypoxic stunting of growth and size can occur as programmed inhibition of growth, often by inhibition of insulin stimulation of growth processes. Furthermore, there is increasing evidence that these same O<inf>2</inf> signaling pathways can be utilized during normal animal development to ensure matching of O<inf>2</inf> supply and demand structures and in mediation of variation in animal performance.

Original languageEnglish (US)
Pages (from-to)455-470
Number of pages16
JournalPhysiological and Biochemical Zoology
Volume88
Issue number5
DOIs
StatePublished - Sep 1 2015

Fingerprint

hypoxia
Growth Disorders
growth retardation
Animals
organisms
Growth
animal development
Adenosine Triphosphate
resting metabolic rate
supply balance
animal performance
Basal Metabolism
Mammals
ontogeny
Invertebrates
animals
insulin
Metabolism
invertebrates
vertebrates

Keywords

  • Growth
  • Hypoxia
  • Signaling
  • Size

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Physiology
  • Biochemistry

Cite this

Stunted by developing in hypoxia : Linking comparative and model organism studies. / Harrison, Jon; Shingleton, Alexander W.; Callier, Viviane.

In: Physiological and Biochemical Zoology, Vol. 88, No. 5, 01.09.2015, p. 455-470.

Research output: Contribution to journalArticle

Harrison, Jon ; Shingleton, Alexander W. ; Callier, Viviane. / Stunted by developing in hypoxia : Linking comparative and model organism studies. In: Physiological and Biochemical Zoology. 2015 ; Vol. 88, No. 5. pp. 455-470.
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