Studying Population Genetic Processes in Viruses: From Drug-Resistance Evolution to Patient Infection Dynamics

Jeffrey D. Jensen

doi:10.1016/B978-0-12-814515-9.00113-2

Studying Population Genetic Processes in Viruses: From Drug-Resistance Evolution to Patient Infection Dynamics

Jeffrey D. Jensen

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

Abstract

I here present a brief overview of the population genetic processes shaping within and between levels and patterns of variation and divergence in viral populations - emphasizing the importance of accounting for the constantly operating evolutionary processes of genetic drift (as modulated by infection dynamics) and purifying selection, prior to quantifying periodic evolutionary processes such as positive selection (associated with, for example, drug-resistance).

Original language	English (US)
Title of host publication	Encyclopedia of Virology
Subtitle of host publication	Volume 1-5, Fourth Edition
Publisher	Elsevier
Pages	227-232
Number of pages	6
Volume	1-5
ISBN (Electronic)	9780128145166
DOIs	https://doi.org/10.1016/B978-0-12-814515-9.00113-2
State	Published - Jan 1 2020
Externally published	Yes

Keywords

Background selection
Coalescent theory
Demography
Direct selection
Genetic hitchhiking
Genomic scans for selection
Hill-Robertson interference
Kingman coalescent
Linked selection effects
Multiple-merger coalescent
Population genetics
Selective sweeps

ASJC Scopus subject areas

General Immunology and Microbiology

Access to Document

10.1016/B978-0-12-814515-9.00113-2

Cite this

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title = "Studying Population Genetic Processes in Viruses: From Drug-Resistance Evolution to Patient Infection Dynamics",

abstract = "I here present a brief overview of the population genetic processes shaping within and between levels and patterns of variation and divergence in viral populations - emphasizing the importance of accounting for the constantly operating evolutionary processes of genetic drift (as modulated by infection dynamics) and purifying selection, prior to quantifying periodic evolutionary processes such as positive selection (associated with, for example, drug-resistance).",

keywords = "Background selection, Coalescent theory, Demography, Direct selection, Genetic hitchhiking, Genomic scans for selection, Hill-Robertson interference, Kingman coalescent, Linked selection effects, Multiple-merger coalescent, Population genetics, Selective sweeps",

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doi = "10.1016/B978-0-12-814515-9.00113-2",

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N2 - I here present a brief overview of the population genetic processes shaping within and between levels and patterns of variation and divergence in viral populations - emphasizing the importance of accounting for the constantly operating evolutionary processes of genetic drift (as modulated by infection dynamics) and purifying selection, prior to quantifying periodic evolutionary processes such as positive selection (associated with, for example, drug-resistance).

AB - I here present a brief overview of the population genetic processes shaping within and between levels and patterns of variation and divergence in viral populations - emphasizing the importance of accounting for the constantly operating evolutionary processes of genetic drift (as modulated by infection dynamics) and purifying selection, prior to quantifying periodic evolutionary processes such as positive selection (associated with, for example, drug-resistance).

KW - Background selection

KW - Coalescent theory

KW - Demography

KW - Direct selection

KW - Genetic hitchhiking

KW - Genomic scans for selection

KW - Hill-Robertson interference

KW - Kingman coalescent

KW - Linked selection effects

KW - Multiple-merger coalescent

KW - Population genetics

KW - Selective sweeps

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DO - 10.1016/B978-0-12-814515-9.00113-2

M3 - Chapter

AN - SCOPUS:85148819122

VL - 1-5

SP - 227

EP - 232

BT - Encyclopedia of Virology

PB - Elsevier

ER -

Studying Population Genetic Processes in Viruses: From Drug-Resistance Evolution to Patient Infection Dynamics

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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