Study of the properties of biotin-streptavidin sensitive biofets

Thomas Windbacher, Viktor Sverdlov, Siegfried Selberherr, Clemens Heitzinger, Norbert Mauser, Christian Ringhofer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work the properties of a biotin-streptavidin BioFET have been studied numerically with homogenized boundary interface conditions as the link between the oxide of the FET and the analyte which contains the bio-sample. The biotin-streptavidin reaction pair is used in purification and detection of various biomolecules; the strong streptavidin-biotin bond can also be used to attach biomolecules to one another or onto a solid support. Thus this reaction pair in combination with a FET as the transducer is a powerful setup enabling the detection of a wide variety of molecules with many advantages that stem from the FET, like no labeling, no need of expensive read-out devices, the possibility to put the signal amplification and analysis on the same chip, and outdoor usage without the necessity of a lab.

Original languageEnglish (US)
Title of host publicationBIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices
Pages24-30
Number of pages7
StatePublished - 2009
Event2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 - Porto, Portugal
Duration: Jan 14 2009Jan 17 2009

Other

Other2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009
CountryPortugal
CityPorto
Period1/14/091/17/09

Fingerprint

Field effect transistors
Biomolecules
Labeling
Purification
Amplification
Transducers
Molecules
Oxides
Biotin

Keywords

  • BioFET
  • Biotin-streptavidin
  • Field-effect biosensor
  • Interface conditions
  • Multi-scale problem
  • Simulation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Windbacher, T., Sverdlov, V., Selberherr, S., Heitzinger, C., Mauser, N., & Ringhofer, C. (2009). Study of the properties of biotin-streptavidin sensitive biofets. In BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices (pp. 24-30)

Study of the properties of biotin-streptavidin sensitive biofets. / Windbacher, Thomas; Sverdlov, Viktor; Selberherr, Siegfried; Heitzinger, Clemens; Mauser, Norbert; Ringhofer, Christian.

BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices. 2009. p. 24-30.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Windbacher, T, Sverdlov, V, Selberherr, S, Heitzinger, C, Mauser, N & Ringhofer, C 2009, Study of the properties of biotin-streptavidin sensitive biofets. in BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices. pp. 24-30, 2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009, Porto, Portugal, 1/14/09.
Windbacher T, Sverdlov V, Selberherr S, Heitzinger C, Mauser N, Ringhofer C. Study of the properties of biotin-streptavidin sensitive biofets. In BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices. 2009. p. 24-30
Windbacher, Thomas ; Sverdlov, Viktor ; Selberherr, Siegfried ; Heitzinger, Clemens ; Mauser, Norbert ; Ringhofer, Christian. / Study of the properties of biotin-streptavidin sensitive biofets. BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices. 2009. pp. 24-30
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