TY - GEN
T1 - Study of the properties of biotin-streptavidin sensitive biofets
AU - Windbacher, Thomas
AU - Sverdlov, Viktor
AU - Selberherr, Siegfried
AU - Heitzinger, Clemens
AU - Mauser, Norbert
AU - Ringhofer, Christian
PY - 2009
Y1 - 2009
N2 - In this work the properties of a biotin-streptavidin BioFET have been studied numerically with homogenized boundary interface conditions as the link between the oxide of the FET and the analyte which contains the bio-sample. The biotin-streptavidin reaction pair is used in purification and detection of various biomolecules; the strong streptavidin-biotin bond can also be used to attach biomolecules to one another or onto a solid support. Thus this reaction pair in combination with a FET as the transducer is a powerful setup enabling the detection of a wide variety of molecules with many advantages that stem from the FET, like no labeling, no need of expensive read-out devices, the possibility to put the signal amplification and analysis on the same chip, and outdoor usage without the necessity of a lab.
AB - In this work the properties of a biotin-streptavidin BioFET have been studied numerically with homogenized boundary interface conditions as the link between the oxide of the FET and the analyte which contains the bio-sample. The biotin-streptavidin reaction pair is used in purification and detection of various biomolecules; the strong streptavidin-biotin bond can also be used to attach biomolecules to one another or onto a solid support. Thus this reaction pair in combination with a FET as the transducer is a powerful setup enabling the detection of a wide variety of molecules with many advantages that stem from the FET, like no labeling, no need of expensive read-out devices, the possibility to put the signal amplification and analysis on the same chip, and outdoor usage without the necessity of a lab.
KW - BioFET
KW - Biotin-streptavidin
KW - Field-effect biosensor
KW - Interface conditions
KW - Multi-scale problem
KW - Simulation
UR - http://www.scopus.com/inward/record.url?scp=67650550019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650550019&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:67650550019
SN - 9789898111647
T3 - BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices
SP - 24
EP - 30
BT - BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices
T2 - 2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009
Y2 - 14 January 2009 through 17 January 2009
ER -