Study of the properties of biotin-streptavidin sensitive biofets

Thomas Windbacher, Viktor Sverdlov, Siegfried Selberherr, Clemens Heitzinger, Norbert Mauser, Christian Ringhofer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work the properties of a biotin-streptavidin BioFET have been studied numerically with homogenized boundary interface conditions as the link between the oxide of the FET and the analyte which contains the bio-sample. The biotin-streptavidin reaction pair is used in purification and detection of various biomolecules; the strong streptavidin-biotin bond can also be used to attach biomolecules to one another or onto a solid support. Thus this reaction pair in combination with a FET as the transducer is a powerful setup enabling the detection of a wide variety of molecules with many advantages that stem from the FET, like no labeling, no need of expensive read-out devices, the possibility to put the signal amplification and analysis on the same chip, and outdoor usage without the necessity of a lab.

Original languageEnglish (US)
Title of host publicationBIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices
Pages24-30
Number of pages7
StatePublished - Jul 21 2009
Event2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 - Porto, Portugal
Duration: Jan 14 2009Jan 17 2009

Publication series

NameBIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices

Other

Other2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009
CountryPortugal
CityPorto
Period1/14/091/17/09

Keywords

  • BioFET
  • Biotin-streptavidin
  • Field-effect biosensor
  • Interface conditions
  • Multi-scale problem
  • Simulation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Windbacher, T., Sverdlov, V., Selberherr, S., Heitzinger, C., Mauser, N., & Ringhofer, C. (2009). Study of the properties of biotin-streptavidin sensitive biofets. In BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices (pp. 24-30). (BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices).