Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium. II. Structures of New Pregnane Glycosides, Periplocosides A, B and C

Hideji Itokawa, Jun-Ping Xu, Koichi Takeya, Kinzo Watanabe, Junzo Shoji

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Three new pregnane glycosides, named periplocosides A, B and C, have been isolated from the antitumor fraction, which was obtained by subjecting the CHC13 extract of Periploca sepium to column chromatography over silica gel and eluting with CHCl3-MeOH (10: 1). Their structures were established by various nuclear magnetic resonance techniques and chemical evidence. The major constituents, periplocoside A, showed significant antitumor activity against Sarcoma 180 ascites in mice.

Original languageEnglish (US)
Pages (from-to)982-987
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume36
Issue number3
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Periploca
Sepia
Sarcoma 180
Column chromatography
Silica Gel
Ascites
Chromatography
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
pregnane glycoside
periplocoside A
periplocoside C
periplocoside B

Keywords

  • 2D-NMR
  • 7-dideoxy-4-O-methyl-αD-gluco-2-heptulose
  • C-1H long-range pregnane glycoside 3
  • antitumor substance
  • Asclepiadaceae
  • Periploca sepium
  • periplocoside A

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

Cite this

Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium. II. Structures of New Pregnane Glycosides, Periplocosides A, B and C. / Itokawa, Hideji; Xu, Jun-Ping; Takeya, Koichi; Watanabe, Kinzo; Shoji, Junzo.

In: Chemical and Pharmaceutical Bulletin, Vol. 36, No. 3, 01.01.1988, p. 982-987.

Research output: Contribution to journalArticle

Itokawa, Hideji ; Xu, Jun-Ping ; Takeya, Koichi ; Watanabe, Kinzo ; Shoji, Junzo. / Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium. II. Structures of New Pregnane Glycosides, Periplocosides A, B and C. In: Chemical and Pharmaceutical Bulletin. 1988 ; Vol. 36, No. 3. pp. 982-987.
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