Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium. II. Structures of New Pregnane Glycosides, Periplocosides A, B and C

Hideji Itokawa; Junping Xu; Koichi Takeya; Kinzo Watanabe; Junzo Shoji

doi:10.1248/cpb.36.982

Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium. II. Structures of New Pregnane Glycosides, Periplocosides A, B and C

Hideji Itokawa, Junping Xu, Koichi Takeya, Kinzo Watanabe, Junzo Shoji

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Three new pregnane glycosides, named periplocosides A, B and C, have been isolated from the antitumor fraction, which was obtained by subjecting the CHC1₃ extract of Periploca sepium to column chromatography over silica gel and eluting with CHCl₃-MeOH (10: 1). Their structures were established by various nuclear magnetic resonance techniques and chemical evidence. The major constituents, periplocoside A, showed significant antitumor activity against Sarcoma 180 ascites in mice.

Original language	English (US)
Pages (from-to)	982-987
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	36
Issue number	3
DOIs	https://doi.org/10.1248/cpb.36.982
State	Published - 1988
Externally published	Yes

Keywords

2D-NMR
7-dideoxy-4-O-methyl-αD-gluco-2-heptulose
Asclepiadaceae
C-1H long-range pregnane glycoside 3
Periploca sepium
antitumor substance
periplocoside A

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.36.982

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title = "Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium. II. Structures of New Pregnane Glycosides, Periplocosides A, B and C",

abstract = "Three new pregnane glycosides, named periplocosides A, B and C, have been isolated from the antitumor fraction, which was obtained by subjecting the CHC13 extract of Periploca sepium to column chromatography over silica gel and eluting with CHCl3-MeOH (10: 1). Their structures were established by various nuclear magnetic resonance techniques and chemical evidence. The major constituents, periplocoside A, showed significant antitumor activity against Sarcoma 180 ascites in mice.",

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author = "Hideji Itokawa and Junping Xu and Koichi Takeya and Kinzo Watanabe and Junzo Shoji",

year = "1988",

doi = "10.1248/cpb.36.982",

language = "English (US)",

volume = "36",

pages = "982--987",

journal = "Chemical and Pharmaceutical Bulletin",

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publisher = "Pharmaceutical Society of Japan",

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T1 - Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium. II. Structures of New Pregnane Glycosides, Periplocosides A, B and C

AU - Itokawa, Hideji

AU - Xu, Junping

AU - Takeya, Koichi

AU - Watanabe, Kinzo

AU - Shoji, Junzo

PY - 1988

Y1 - 1988

N2 - Three new pregnane glycosides, named periplocosides A, B and C, have been isolated from the antitumor fraction, which was obtained by subjecting the CHC13 extract of Periploca sepium to column chromatography over silica gel and eluting with CHCl3-MeOH (10: 1). Their structures were established by various nuclear magnetic resonance techniques and chemical evidence. The major constituents, periplocoside A, showed significant antitumor activity against Sarcoma 180 ascites in mice.

AB - Three new pregnane glycosides, named periplocosides A, B and C, have been isolated from the antitumor fraction, which was obtained by subjecting the CHC13 extract of Periploca sepium to column chromatography over silica gel and eluting with CHCl3-MeOH (10: 1). Their structures were established by various nuclear magnetic resonance techniques and chemical evidence. The major constituents, periplocoside A, showed significant antitumor activity against Sarcoma 180 ascites in mice.

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KW - 7-dideoxy-4-O-methyl-αD-gluco-2-heptulose

KW - Asclepiadaceae

KW - C-1H long-range pregnane glycoside 3

KW - Periploca sepium

KW - antitumor substance

KW - periplocoside A

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Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium. II. Structures of New Pregnane Glycosides, Periplocosides A, B and C

Abstract

Keywords

ASJC Scopus subject areas

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