Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore

James McNulty, Justin Mao, Romelo Gibe, Ruowei Mo, Sonja Wolf, George Pettit, Delbert L. Herald, Michael R. Boyd

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number2
DOIs
StatePublished - Jan 22 2001

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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