Abstract
Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that reveal conformationally distinct active states within this unique kinase family.
Original language | English (US) |
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Pages (from-to) | 3058-3073 |
Number of pages | 16 |
Journal | Cellular and Molecular Life Sciences |
Volume | 65 |
Issue number | 19 |
DOIs | |
State | Published - Oct 2008 |
Keywords
- Gaussian Network Model
- Hydrogen exchange mass spectrometry
- SH2 domain
- SH3 domain
- Src-family kinases
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Cellular and Molecular Neuroscience
- Cell Biology