Structure and dynamic regulation of Src-family kinases

J. R. Engen, T. E. Wales, J. M. Hochrein, M. A. Meyn, Sefika Ozkan, I. Bahar, T. E. Smithgall

Research output: Contribution to journalReview articlepeer-review

125 Scopus citations

Abstract

Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that reveal conformationally distinct active states within this unique kinase family.

Original languageEnglish (US)
Pages (from-to)3058-3073
Number of pages16
JournalCellular and Molecular Life Sciences
Volume65
Issue number19
DOIs
StatePublished - Oct 2008

Keywords

  • Gaussian Network Model
  • Hydrogen exchange mass spectrometry
  • SH2 domain
  • SH3 domain
  • Src-family kinases

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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