Structural biochemistry. Part XII. Synthesis of tobacco mosaic virus protein unit 150-158

George Pettit, Shyam K. Gupta, Richard H. Ode

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Abstract

The C-terminal nonapeptide sequence of tobacco mosaic virus protein was synthesized by a fragment-condensation approach. Important steps in the synthesis involved coupling of N-benzyloxycarbonyl-L-threonyl-L-serine azide with glycyl-L-prolyl-L-alanyl-L-threonine methyl ester and condensing the mixed carbonic anhydride derived from N-t-butoxycarbonyl-L-leucyl-L-valyl-L-tryptophan and isobutyl chloroformate with the hexapeptide (Vb) to provide the nonapeptide N-t-butoxycarbonyl-L-leucyl-L-valyl-L-tryptophyl-L-threonyl-L-seryl-glycyl-L- prolyl-L-alanyl-L-threonine (VIIIb).

Original languageEnglish (US)
Pages (from-to)950-954
Number of pages5
JournalJournal of the Chemical Society, Perkin Transactions 1
DOIs
StatePublished - Jan 1 1973

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ASJC Scopus subject areas

  • Chemistry(all)

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