STRUCTURAL BIOCHEMISTRY 17. Synthesis of Tryptophan Dipeptides

George Pettit, T. S. Krupa, R. M. Reynolds

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Boc‐Trp‐Leu hydrazide has been found to significantly inhibit growth of the L‐1210 and P388 murine lymphocytic leukemias. A series of related tryptophan dipeptides were prepared and found to be devoid of such activity. The tryptophan dipeptides were most conveniently obtained employing the DCCI‐NHS peptide bond‐forming procedure.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalInternational Journal of Peptide and Protein Research
Volume14
Issue number3
DOIs
StatePublished - Sep 1979

Keywords

  • antineoplastic activity
  • tryptophan dipeptides

ASJC Scopus subject areas

  • Biochemistry

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