Structural and biophysical mechanisms underlying dynamic sensitivity of primary sensory interneurons in the cricket cercal sensory system

G. I. Cummins, S. M. Crook, A. G. Dimitrov, T. Ganje, Gwen A. Jacobs, J. P. Miller

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We constructed probabilistic models of afferent inputs and compartmental models of interneurons in the cricket cercal system to examine the effects of dendritic morphology, distribution of synaptic inputs, and membrane properties on interneuron directional tuning properties. The mean directional tuning of afferent inputs to an interneuron was an excellent predictor of its directional tuning. Location of the synapses on the interneurons' dendrites was not essential to determining tuning characteristics, but had a substantial effect on sensitivity. Thus, we conclude that both sampling of the afferent population, and anatomical distribution of synaptic inputs are important determinants of an interneuron's directional response.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalNeurocomputing
Volume52-54
DOIs
StatePublished - Jun 2003
Externally publishedYes

Keywords

  • Compartment models
  • Gaussian mixtures
  • Neural maps
  • Sensory systems
  • Structure/function

ASJC Scopus subject areas

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence

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