Abstract

Atypical brainstem modulation of pain might contribute to changes in sensory processing typical of migraine. The study objective was to investigate whether migraine is associated with brainstem structural alterations that correlate with this altered pain processing. MRI T1-weighted images of 55 migraine patients and 58 healthy controls were used to: (1) create deformable mesh models of the brainstem that allow for shape analyses; (2) calculate volumes of the midbrain, pons, medulla and the superior cerebellar peduncles; (3) interrogate correlations between regional brainstem volumes, cutaneous heat pain thresholds, and allodynia symptoms. Migraineurs had smaller midbrain volumes (healthy controls = 61.28 mm3, SD = 5.89; migraineurs = 58.80 mm3, SD = 6.64; p = 0.038), and significant (p < 0.05) inward deformations in the ventral midbrain and pons, and outward deformations in the lateral medulla and dorsolateral pons relative to healthy controls. Migraineurs had a negative correlation between ASC-12 allodynia symptom severity with midbrain volume (r = − 0.32; p = 0.019) and a positive correlation between cutaneous heat pain thresholds with medulla (r = 0.337; p = 0.012) and cerebellar peduncle volumes (r = 0.435; p = 0.001). Migraineurs with greater symptoms of allodynia have smaller midbrain volumes and migraineurs with lower heat pain thresholds have smaller medulla and cerebellar peduncles. The brainstem likely plays a role in altered sensory processing in migraine and brainstem structure might reflect severity of allodynia and hypersensitivity to pain in migraine.

Original languageEnglish (US)
Pages (from-to)223-227
Number of pages5
JournalNeuroImage: Clinical
Volume13
DOIs
StatePublished - 2017

Fingerprint

Migraine Disorders
Brain Stem
Mesencephalon
Hyperalgesia
Pain Threshold
Pons
Hot Temperature
Pain
Skin
Hypersensitivity

Keywords

  • Allodynia
  • Brainstem
  • Magnetic resonance imaging
  • Migraine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Structural alterations of the brainstem in migraine. / Chong, Catherine D.; Plasencia, Jonathan D.; Frakes, David; Schwedt, Todd J.

In: NeuroImage: Clinical, Vol. 13, 2017, p. 223-227.

Research output: Contribution to journalArticle

Chong, Catherine D. ; Plasencia, Jonathan D. ; Frakes, David ; Schwedt, Todd J. / Structural alterations of the brainstem in migraine. In: NeuroImage: Clinical. 2017 ; Vol. 13. pp. 223-227.
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