Stroke

Working toward a prioritized world agenda

Vladimir Hachinski, Geoffrey A. Donnan, Philip B. Gorelick, Werner Hacke, Steven C. Cramer, Markku Kaste, Marc Fisher, Michael Brainin, Alastair M. Buchan, Eng H. Lo, Brett E. Skolnick, Karen L. Furie, Graeme J. Hankey, Miia Kivipelto, John Morris, Peter M. Rothwell, Ralph L. Sacco, Sidney C. Smith, Yulun Wang, Alan Bryer & 33 others Gary A. Ford, Costantino Iadecola, Sheila C O Martins, Jeff Saver, Veronika Skvortsova, Mark Bayley, Martin M. Bednar, Pamela Duncan, Lori Enney, Seth Finklestein, Theresa A. Jones, Lalit Kalra, Jeffrey Kleim, Ralph Nitkin, Robert Teasell, Cornelius Weiller, Bhupat Desai, Mark P. Goldberg, Wolf Dieter Heiss, Osmo Saarelma, Lee H. Schwamm, Yukito Shinohara, Bhargava Trivedi, Nils Wahlgren, Lawrence K. Wong, Antoine Hakim, Bo Norrving, Stephen Prudhomme, Natan M. Bornstein, Stephen M. Davis, Larry B. Goldstein, Didier Leys, Jaakko Tuomilehto

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Background and Purpose: The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke. Methods: Preliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium. RESULTS: Recommendations of the Synergium are:Basic Science, Drug Development and Technology: There is a need to develop: (1) New systems of working together to break down the prevalent silog mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science.Stroke Prevention: (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (eg, social media/marketing) techniques.Acute Stroke Management: Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks.Brain Recovery and Rehabilitation: (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery.Into the 21st Century: Web, Technology and Communications: (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized electronic archives and registries.Foster Cooperation Among Stakeholders (large stroke organizations, nongovernmental organizations, governments, patient organizations and industry) to enhance stroke care.Educate and energize professionals, patients, the public and policy makers by using a Brain Health concept that enables promotion of preventive measures. Conclusions: To accelerate progress in stroke, we must reach beyond the current status scientifically, conceptually, and pragmatically. Advances can be made not only by doing, but ceasing to do. Significant savings in time, money, and effort could result from discontinuing practices driven by unsubstantiated opinion, unproven approaches, and financial gain. Systematic integration of knowledge into programs coupled with careful evaluation can speed the pace of progress.

Original languageEnglish (US)
Pages (from-to)1084-1099
Number of pages16
JournalStroke
Volume41
Issue number6
DOIs
StatePublished - Jun 2010
Externally publishedYes

Fingerprint

Stroke
Organizations
Rehabilitation
Social Marketing
Social Media
Technology
Health Communication
Cerebrovascular Disorders
Executive Function
Brain
Emergency Medical Services
Public Policy
Neurosciences
Administrative Personnel
Research
Registries
Consensus
Industry
Chronic Disease
Public Health

Keywords

  • Prevention
  • Rehabilitation
  • Stroke
  • Translational
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Hachinski, V., Donnan, G. A., Gorelick, P. B., Hacke, W., Cramer, S. C., Kaste, M., ... Tuomilehto, J. (2010). Stroke: Working toward a prioritized world agenda. Stroke, 41(6), 1084-1099. https://doi.org/10.1161/STROKEAHA.110.586156

Stroke : Working toward a prioritized world agenda. / Hachinski, Vladimir; Donnan, Geoffrey A.; Gorelick, Philip B.; Hacke, Werner; Cramer, Steven C.; Kaste, Markku; Fisher, Marc; Brainin, Michael; Buchan, Alastair M.; Lo, Eng H.; Skolnick, Brett E.; Furie, Karen L.; Hankey, Graeme J.; Kivipelto, Miia; Morris, John; Rothwell, Peter M.; Sacco, Ralph L.; Smith, Sidney C.; Wang, Yulun; Bryer, Alan; Ford, Gary A.; Iadecola, Costantino; Martins, Sheila C O; Saver, Jeff; Skvortsova, Veronika; Bayley, Mark; Bednar, Martin M.; Duncan, Pamela; Enney, Lori; Finklestein, Seth; Jones, Theresa A.; Kalra, Lalit; Kleim, Jeffrey; Nitkin, Ralph; Teasell, Robert; Weiller, Cornelius; Desai, Bhupat; Goldberg, Mark P.; Heiss, Wolf Dieter; Saarelma, Osmo; Schwamm, Lee H.; Shinohara, Yukito; Trivedi, Bhargava; Wahlgren, Nils; Wong, Lawrence K.; Hakim, Antoine; Norrving, Bo; Prudhomme, Stephen; Bornstein, Natan M.; Davis, Stephen M.; Goldstein, Larry B.; Leys, Didier; Tuomilehto, Jaakko.

In: Stroke, Vol. 41, No. 6, 06.2010, p. 1084-1099.

Research output: Contribution to journalArticle

Hachinski, V, Donnan, GA, Gorelick, PB, Hacke, W, Cramer, SC, Kaste, M, Fisher, M, Brainin, M, Buchan, AM, Lo, EH, Skolnick, BE, Furie, KL, Hankey, GJ, Kivipelto, M, Morris, J, Rothwell, PM, Sacco, RL, Smith, SC, Wang, Y, Bryer, A, Ford, GA, Iadecola, C, Martins, SCO, Saver, J, Skvortsova, V, Bayley, M, Bednar, MM, Duncan, P, Enney, L, Finklestein, S, Jones, TA, Kalra, L, Kleim, J, Nitkin, R, Teasell, R, Weiller, C, Desai, B, Goldberg, MP, Heiss, WD, Saarelma, O, Schwamm, LH, Shinohara, Y, Trivedi, B, Wahlgren, N, Wong, LK, Hakim, A, Norrving, B, Prudhomme, S, Bornstein, NM, Davis, SM, Goldstein, LB, Leys, D & Tuomilehto, J 2010, 'Stroke: Working toward a prioritized world agenda', Stroke, vol. 41, no. 6, pp. 1084-1099. https://doi.org/10.1161/STROKEAHA.110.586156
Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M et al. Stroke: Working toward a prioritized world agenda. Stroke. 2010 Jun;41(6):1084-1099. https://doi.org/10.1161/STROKEAHA.110.586156
Hachinski, Vladimir ; Donnan, Geoffrey A. ; Gorelick, Philip B. ; Hacke, Werner ; Cramer, Steven C. ; Kaste, Markku ; Fisher, Marc ; Brainin, Michael ; Buchan, Alastair M. ; Lo, Eng H. ; Skolnick, Brett E. ; Furie, Karen L. ; Hankey, Graeme J. ; Kivipelto, Miia ; Morris, John ; Rothwell, Peter M. ; Sacco, Ralph L. ; Smith, Sidney C. ; Wang, Yulun ; Bryer, Alan ; Ford, Gary A. ; Iadecola, Costantino ; Martins, Sheila C O ; Saver, Jeff ; Skvortsova, Veronika ; Bayley, Mark ; Bednar, Martin M. ; Duncan, Pamela ; Enney, Lori ; Finklestein, Seth ; Jones, Theresa A. ; Kalra, Lalit ; Kleim, Jeffrey ; Nitkin, Ralph ; Teasell, Robert ; Weiller, Cornelius ; Desai, Bhupat ; Goldberg, Mark P. ; Heiss, Wolf Dieter ; Saarelma, Osmo ; Schwamm, Lee H. ; Shinohara, Yukito ; Trivedi, Bhargava ; Wahlgren, Nils ; Wong, Lawrence K. ; Hakim, Antoine ; Norrving, Bo ; Prudhomme, Stephen ; Bornstein, Natan M. ; Davis, Stephen M. ; Goldstein, Larry B. ; Leys, Didier ; Tuomilehto, Jaakko. / Stroke : Working toward a prioritized world agenda. In: Stroke. 2010 ; Vol. 41, No. 6. pp. 1084-1099.
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abstract = "Background and Purpose: The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke. Methods: Preliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium. RESULTS: Recommendations of the Synergium are:Basic Science, Drug Development and Technology: There is a need to develop: (1) New systems of working together to break down the prevalent silog mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science.Stroke Prevention: (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (eg, social media/marketing) techniques.Acute Stroke Management: Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks.Brain Recovery and Rehabilitation: (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery.Into the 21st Century: Web, Technology and Communications: (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized electronic archives and registries.Foster Cooperation Among Stakeholders (large stroke organizations, nongovernmental organizations, governments, patient organizations and industry) to enhance stroke care.Educate and energize professionals, patients, the public and policy makers by using a Brain Health concept that enables promotion of preventive measures. Conclusions: To accelerate progress in stroke, we must reach beyond the current status scientifically, conceptually, and pragmatically. Advances can be made not only by doing, but ceasing to do. Significant savings in time, money, and effort could result from discontinuing practices driven by unsubstantiated opinion, unproven approaches, and financial gain. Systematic integration of knowledge into programs coupled with careful evaluation can speed the pace of progress.",
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T1 - Stroke

T2 - Working toward a prioritized world agenda

AU - Hachinski, Vladimir

AU - Donnan, Geoffrey A.

AU - Gorelick, Philip B.

AU - Hacke, Werner

AU - Cramer, Steven C.

AU - Kaste, Markku

AU - Fisher, Marc

AU - Brainin, Michael

AU - Buchan, Alastair M.

AU - Lo, Eng H.

AU - Skolnick, Brett E.

AU - Furie, Karen L.

AU - Hankey, Graeme J.

AU - Kivipelto, Miia

AU - Morris, John

AU - Rothwell, Peter M.

AU - Sacco, Ralph L.

AU - Smith, Sidney C.

AU - Wang, Yulun

AU - Bryer, Alan

AU - Ford, Gary A.

AU - Iadecola, Costantino

AU - Martins, Sheila C O

AU - Saver, Jeff

AU - Skvortsova, Veronika

AU - Bayley, Mark

AU - Bednar, Martin M.

AU - Duncan, Pamela

AU - Enney, Lori

AU - Finklestein, Seth

AU - Jones, Theresa A.

AU - Kalra, Lalit

AU - Kleim, Jeffrey

AU - Nitkin, Ralph

AU - Teasell, Robert

AU - Weiller, Cornelius

AU - Desai, Bhupat

AU - Goldberg, Mark P.

AU - Heiss, Wolf Dieter

AU - Saarelma, Osmo

AU - Schwamm, Lee H.

AU - Shinohara, Yukito

AU - Trivedi, Bhargava

AU - Wahlgren, Nils

AU - Wong, Lawrence K.

AU - Hakim, Antoine

AU - Norrving, Bo

AU - Prudhomme, Stephen

AU - Bornstein, Natan M.

AU - Davis, Stephen M.

AU - Goldstein, Larry B.

AU - Leys, Didier

AU - Tuomilehto, Jaakko

PY - 2010/6

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N2 - Background and Purpose: The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke. Methods: Preliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium. RESULTS: Recommendations of the Synergium are:Basic Science, Drug Development and Technology: There is a need to develop: (1) New systems of working together to break down the prevalent silog mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science.Stroke Prevention: (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (eg, social media/marketing) techniques.Acute Stroke Management: Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks.Brain Recovery and Rehabilitation: (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery.Into the 21st Century: Web, Technology and Communications: (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized electronic archives and registries.Foster Cooperation Among Stakeholders (large stroke organizations, nongovernmental organizations, governments, patient organizations and industry) to enhance stroke care.Educate and energize professionals, patients, the public and policy makers by using a Brain Health concept that enables promotion of preventive measures. Conclusions: To accelerate progress in stroke, we must reach beyond the current status scientifically, conceptually, and pragmatically. Advances can be made not only by doing, but ceasing to do. Significant savings in time, money, and effort could result from discontinuing practices driven by unsubstantiated opinion, unproven approaches, and financial gain. Systematic integration of knowledge into programs coupled with careful evaluation can speed the pace of progress.

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