Stress and telomere shortening among central Indian conservation refugees

Sammy Zahran, Jeffrey G. Snodgrass, David G. Maranon, Chakrapani Upadhyay, Douglas A. Granger, Susan M. Bailey

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Research links psychosocial stress to premature telomere shortening and accelerated human aging; however, this association has only been demonstrated in so-called "WEIRD" societies (Western, educated, industrialized, rich, and democratic), where stress is typically lower and life expectancies longer. By contrast, we examine stress and telomere shortening in a non-Western setting among a highly stressed population with overall lower life expectancies: poor indigenous people-the Sahariya-who were displaced (between 1998 and 2002) from their ancestral homes in a central Indian wildlife sanctuary. In this setting, we examined adult populations in two representative villages, one relocated to accommodate the introduction of Asiatic lions into the sanctuary (n = 24 individuals), and the other newly isolated in the sanctuary buffer zone after their previous neighbors were moved (n = 22). Our research strategy combined physical stress measures via the salivary analytes cortisol and a-amylase with self-assessments of psychosomatic stress, ethnographic observations, and telomere length assessment [telomere-fluorescence in situ hybridization (TEL-FISH) coupled with 3D imaging of buccal cell nuclei], providing high-resolution data amenable to multilevel statistical analysis. Consistent with expectations, we found significant associations between each of our stress measures-the two salivary analytes and the psychosomatic symptom survey-and telomere length, after adjusting for relevant behavioral, health, and demographic traits. As the first study (to our knowledge) to link stress to telomere length in a non-WEIRD population, our research strengthens the case for stress-induced telomere shortening as a pancultural biomarker of compromised health and aging.

Original languageEnglish (US)
Pages (from-to)E928-E936
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number9
DOIs
StatePublished - Mar 3 2015

Fingerprint

Telomere Shortening
Refugees
Telomere
Life Expectancy
Research
Lions
Population
Multilevel Analysis
Cheek
Health
Amylases
Cell Nucleus
Fluorescence In Situ Hybridization
Hydrocortisone
Buffers
Biomarkers
Demography

Keywords

  • Human displacement
  • India
  • Indigenous peoples
  • Stress
  • Telomeres

ASJC Scopus subject areas

  • General

Cite this

Stress and telomere shortening among central Indian conservation refugees. / Zahran, Sammy; Snodgrass, Jeffrey G.; Maranon, David G.; Upadhyay, Chakrapani; Granger, Douglas A.; Bailey, Susan M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 9, 03.03.2015, p. E928-E936.

Research output: Contribution to journalArticle

Zahran, Sammy ; Snodgrass, Jeffrey G. ; Maranon, David G. ; Upadhyay, Chakrapani ; Granger, Douglas A. ; Bailey, Susan M. / Stress and telomere shortening among central Indian conservation refugees. In: Proceedings of the National Academy of Sciences of the United States of America. 2015 ; Vol. 112, No. 9. pp. E928-E936.
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