Streptomyces: a host for heterologous gene expression

Mary Brawner; George Poste; Martin Rosenberg; Janet Westpheling

doi:10.1016/0958-1669(91)90033-2

Streptomyces: a host for heterologous gene expression

Mary Brawner, George Poste, Martin Rosenberg, Janet Westpheling

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Streptomyces species offer many potential advantages as hosts for the expression and secretion of eukaryotic gene products. In this review we discuss the expression and localization signals that have been used to direct heterologous gene expression and the applications of these signals. Finally, we discuss future strategies aimed at increasing the capacity of this host for the high level production of biologically active eukaryotic gene products.

Original language	English (US)
Pages (from-to)	674-681
Number of pages	8
Journal	Current Opinion in Biotechnology
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/0958-1669(91)90033-2
State	Published - Oct 1991
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/0958-1669(91)90033-2

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title = "Streptomyces: a host for heterologous gene expression",

abstract = "Streptomyces species offer many potential advantages as hosts for the expression and secretion of eukaryotic gene products. In this review we discuss the expression and localization signals that have been used to direct heterologous gene expression and the applications of these signals. Finally, we discuss future strategies aimed at increasing the capacity of this host for the high level production of biologically active eukaryotic gene products.",

author = "Mary Brawner and George Poste and Martin Rosenberg and Janet Westpheling",

year = "1991",

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AU - Rosenberg, Martin

AU - Westpheling, Janet

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AB - Streptomyces species offer many potential advantages as hosts for the expression and secretion of eukaryotic gene products. In this review we discuss the expression and localization signals that have been used to direct heterologous gene expression and the applications of these signals. Finally, we discuss future strategies aimed at increasing the capacity of this host for the high level production of biologically active eukaryotic gene products.

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Streptomyces: a host for heterologous gene expression

Abstract

ASJC Scopus subject areas

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