Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis

A multicentre international study

Palak J. Trivedi, Willem J. Lammers, Henk R. Van Buuren, Albert Parés, Annarosa Floreani, Harry L A Janssen, Pietro Invernizzi, Pier Maria Battezzati, Cyriel Y. Ponsioen, Christophe Corpechot, Raoul Poupon, Marlyn J. Mayo, Andrew K. Burroughs, Frederik Nevens, Andrew L. Mason, Kris V. Kowdley, Ana Lleo, Llorenç Caballeria, Keith Lindor, Bettina E. Hansen & 1 others Gideon M. Hirschfield

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC. Design Risk factor analysis was performed in over 15 centres from North America and Europe spanning >40 years observation period using Cox proportional hazards assumptions, logistic regression, and Kaplan- Meier estimates. Results Of 4565 patients with PBC 123 developed HCC, yielding an incidence rate (IR) of 3.4 cases/1000 patient-years. HCC was significantly more common in men (p

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalGut
Volume65
Issue number2
DOIs
StatePublished - Feb 1 2016

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Biliary Liver Cirrhosis
Multicenter Studies
Hepatocellular Carcinoma
Kaplan-Meier Estimate
North America
Statistical Factor Analysis
Logistic Models
Observation
Incidence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Trivedi, P. J., Lammers, W. J., Van Buuren, H. R., Parés, A., Floreani, A., Janssen, H. L. A., ... Hirschfield, G. M. (2016). Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study. Gut, 65(2), 321-329. https://doi.org/10.1136/gutjnl-2014-308351

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis : A multicentre international study. / Trivedi, Palak J.; Lammers, Willem J.; Van Buuren, Henk R.; Parés, Albert; Floreani, Annarosa; Janssen, Harry L A; Invernizzi, Pietro; Battezzati, Pier Maria; Ponsioen, Cyriel Y.; Corpechot, Christophe; Poupon, Raoul; Mayo, Marlyn J.; Burroughs, Andrew K.; Nevens, Frederik; Mason, Andrew L.; Kowdley, Kris V.; Lleo, Ana; Caballeria, Llorenç; Lindor, Keith; Hansen, Bettina E.; Hirschfield, Gideon M.

In: Gut, Vol. 65, No. 2, 01.02.2016, p. 321-329.

Research output: Contribution to journalArticle

Trivedi, PJ, Lammers, WJ, Van Buuren, HR, Parés, A, Floreani, A, Janssen, HLA, Invernizzi, P, Battezzati, PM, Ponsioen, CY, Corpechot, C, Poupon, R, Mayo, MJ, Burroughs, AK, Nevens, F, Mason, AL, Kowdley, KV, Lleo, A, Caballeria, L, Lindor, K, Hansen, BE & Hirschfield, GM 2016, 'Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study', Gut, vol. 65, no. 2, pp. 321-329. https://doi.org/10.1136/gutjnl-2014-308351
Trivedi PJ, Lammers WJ, Van Buuren HR, Parés A, Floreani A, Janssen HLA et al. Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study. Gut. 2016 Feb 1;65(2):321-329. https://doi.org/10.1136/gutjnl-2014-308351
Trivedi, Palak J. ; Lammers, Willem J. ; Van Buuren, Henk R. ; Parés, Albert ; Floreani, Annarosa ; Janssen, Harry L A ; Invernizzi, Pietro ; Battezzati, Pier Maria ; Ponsioen, Cyriel Y. ; Corpechot, Christophe ; Poupon, Raoul ; Mayo, Marlyn J. ; Burroughs, Andrew K. ; Nevens, Frederik ; Mason, Andrew L. ; Kowdley, Kris V. ; Lleo, Ana ; Caballeria, Llorenç ; Lindor, Keith ; Hansen, Bettina E. ; Hirschfield, Gideon M. / Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis : A multicentre international study. In: Gut. 2016 ; Vol. 65, No. 2. pp. 321-329.
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AU - Parés, Albert

AU - Floreani, Annarosa

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AU - Hansen, Bettina E.

AU - Hirschfield, Gideon M.

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