Strategies that modulate inflammasomes - Insights from host-pathogen interactions

James B. Johnston, Masmudur Rahman, Douglas McFadden

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The innate immune system is a dynamic and complex network for recognizing and responding to cellular insult or tissue damage after infection or injury. The primary effector mechanism of innate immunity is the generation of acute and chronic inflammatory responses through regulation of the processing and activation of proinflammatory caspases, particularly caspase 1, and cytokines, most notably IL-1β and IL-18. Inflammasomes, cytosolic multi-protein complexes that function as molecular scaffolds for caspase activation, have recently emerged as the pivotal mechanism by which host innate immune and inflammatory responses are regulated. In this review, we investigate the mechanisms by which inflammasomes are modulated, both by endogenous host systems and by microbial pathogens.

Original languageEnglish (US)
Pages (from-to)261-274
Number of pages14
JournalSeminars in Immunopathology
Volume29
Issue number3
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

Fingerprint

Inflammasomes
Host-Pathogen Interactions
Caspases
Innate Immunity
Caspase 1
Interleukin-18
Interleukin-1
Immune System
Cytokines
Wounds and Injuries
Infection
Proteins

Keywords

  • Host-pathogen interaction
  • Immune modulation
  • Inflammasome inhibitors
  • Innate immunity
  • Pyrin domain

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Strategies that modulate inflammasomes - Insights from host-pathogen interactions. / Johnston, James B.; Rahman, Masmudur; McFadden, Douglas.

In: Seminars in Immunopathology, Vol. 29, No. 3, 01.09.2007, p. 261-274.

Research output: Contribution to journalReview article

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