Fullerenes are sphere-like molecules with unique physico-chemical properties, which render them of particular interest in biomedical research, consumer products and industrial applications. Human and environmental exposure to fullerenes is not a new phenomenon, due to a long history of hydrocarbon-combustion sources, and will only increase in the future, as incorporation of fullerenes into consumer products becomes more widespread for use as anti-aging, anti-bacterial or anti-apoptotic agents. An essential step in the determination of biological effects of fullerenes (and their surface-functionalized derivatives) is establishment of exposure-assessment techniques. However, in ecotoxicological studies, quantification of fullerenes is performed infrequently because robust, uniformly applicable analytical approaches have yet to be identified, due to the wide variety of sample types. Moreover, the unique physico-chemistry of fullerenes in aqueous matrices requires reassessment of conventional analytical approaches, especially in more complex biological matrices (e.g., urine, blood, plasma, milk, and tissue). Here, we present a review of current analytical approaches for the quantification of fullerenes and propose a consensus approach for determination of these nanomaterials in a variety of environmental and biological matrices.

Original languageEnglish (US)
Pages (from-to)44-57
Number of pages14
JournalTrAC - Trends in Analytical Chemistry
Issue number1
StatePublished - 2011


  • Carbonaceous nanoparticles
  • Environmental impact study
  • Liquid chromatography
  • Liquid-liquid extraction
  • Mass spectrometry
  • Nanomaterial
  • Nanotoxicology
  • Solid-phase extraction
  • Toxicity assessment

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy


Dive into the research topics of 'Strategies for quantifying C<sub>60</sub>fullerenes in environmental and biological samples and implications for studies in environmental health and ecotoxicology'. Together they form a unique fingerprint.

Cite this