Stochastic stage-structured modeling of the adaptive immune system

D. L. Chao, M. P. Davenport, Stephanie Forrest, A. S. Perelson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Citations (Scopus)

Abstract

We have constructed a computer model of the cytotoxic T lymphocyte (CTL) response to antigen and the maintenance of immunological memory. Because immune responses often begin with small numbers of cells and there is great variation among individual immune systems, we have chosen to implement a stochastic model that captures the life cycle of T cells more faithfully than deterministic models. Past models of the immune response have been differential equation based, which do not capture stochastic effects, or agent-based, which are computationally expensive. We use a stochastic stage-structured approach that has many of the advantages of agent-based modeling but is much more efficient. Our model can provide insights into the effect infections have on the CTL repertoire and the response to subsequent infections.

Original languageEnglish (US)
Title of host publicationProceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages124-131
Number of pages8
ISBN (Electronic)0769520006, 9780769520001
DOIs
StatePublished - Jan 1 2003
Externally publishedYes
Event2nd International IEEE Computer Society Computational Systems Bioinformatics Conference, CSB 2003 - Stanford, United States
Duration: Aug 11 2003Aug 14 2003

Other

Other2nd International IEEE Computer Society Computational Systems Bioinformatics Conference, CSB 2003
CountryUnited States
CityStanford
Period8/11/038/14/03

Fingerprint

Immune system
T-cells
Stochastic models
Antigens
Life cycle
Differential equations
Data storage equipment

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications

Cite this

Chao, D. L., Davenport, M. P., Forrest, S., & Perelson, A. S. (2003). Stochastic stage-structured modeling of the adaptive immune system. In Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003 (pp. 124-131). [1227311] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CSB.2003.1227311

Stochastic stage-structured modeling of the adaptive immune system. / Chao, D. L.; Davenport, M. P.; Forrest, Stephanie; Perelson, A. S.

Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003. Institute of Electrical and Electronics Engineers Inc., 2003. p. 124-131 1227311.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chao, DL, Davenport, MP, Forrest, S & Perelson, AS 2003, Stochastic stage-structured modeling of the adaptive immune system. in Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003., 1227311, Institute of Electrical and Electronics Engineers Inc., pp. 124-131, 2nd International IEEE Computer Society Computational Systems Bioinformatics Conference, CSB 2003, Stanford, United States, 8/11/03. https://doi.org/10.1109/CSB.2003.1227311
Chao DL, Davenport MP, Forrest S, Perelson AS. Stochastic stage-structured modeling of the adaptive immune system. In Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003. Institute of Electrical and Electronics Engineers Inc. 2003. p. 124-131. 1227311 https://doi.org/10.1109/CSB.2003.1227311
Chao, D. L. ; Davenport, M. P. ; Forrest, Stephanie ; Perelson, A. S. / Stochastic stage-structured modeling of the adaptive immune system. Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003. Institute of Electrical and Electronics Engineers Inc., 2003. pp. 124-131
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