TY - GEN
T1 - Stochastic stage-structured modeling of the adaptive immune system
AU - Chao, D. L.
AU - Davenport, M. P.
AU - Forrest, S.
AU - Perelson, A. S.
N1 - Publisher Copyright:
© 2003 IEEE.
PY - 2003
Y1 - 2003
N2 - We have constructed a computer model of the cytotoxic T lymphocyte (CTL) response to antigen and the maintenance of immunological memory. Because immune responses often begin with small numbers of cells and there is great variation among individual immune systems, we have chosen to implement a stochastic model that captures the life cycle of T cells more faithfully than deterministic models. Past models of the immune response have been differential equation based, which do not capture stochastic effects, or agent-based, which are computationally expensive. We use a stochastic stage-structured approach that has many of the advantages of agent-based modeling but is much more efficient. Our model can provide insights into the effect infections have on the CTL repertoire and the response to subsequent infections.
AB - We have constructed a computer model of the cytotoxic T lymphocyte (CTL) response to antigen and the maintenance of immunological memory. Because immune responses often begin with small numbers of cells and there is great variation among individual immune systems, we have chosen to implement a stochastic model that captures the life cycle of T cells more faithfully than deterministic models. Past models of the immune response have been differential equation based, which do not capture stochastic effects, or agent-based, which are computationally expensive. We use a stochastic stage-structured approach that has many of the advantages of agent-based modeling but is much more efficient. Our model can provide insights into the effect infections have on the CTL repertoire and the response to subsequent infections.
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U2 - 10.1109/CSB.2003.1227311
DO - 10.1109/CSB.2003.1227311
M3 - Conference contribution
C2 - 16452786
AN - SCOPUS:84960418424
T3 - Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003
SP - 124
EP - 131
BT - Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2nd International IEEE Computer Society Computational Systems Bioinformatics Conference, CSB 2003
Y2 - 11 August 2003 through 14 August 2003
ER -