Stimulation of 5-HT1B receptors decreases cocaine- and sucrose-seeking behavior

Jazmin I. Acosta, Floren A. Boynton, Kenneth F. Kirschner, Janet Neisewander

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Serotonin systems have been implicated in incentive motivation for cocaine, yet little is known about the role of 5-HT1B receptors in these processes. We used the extinction/reinstatement model to examine the effects of the 5-HT1B/1A receptor agonist, RU24969, on reinstatement of extinguished cocaine-seeking behavior. Rats trained to self-administer cocaine subsequently underwent extinction. They were then tested twice for cue and cocaine-primed reinstatement of extinguished cocaine-seeking behavior, receiving saline pretreatment 1 day and their assigned dose of RU24969 (0.3, 1.0, 3.0 mg/kg) the other day. Rats were later trained on a schedule of sucrose reinforcement in novel chambers and then tested for effects of RU24969 on cue reinstatement of sucrose-seeking behavior and locomotion. RU24969 decreased cue and cocaine reinstatement of cocaine-seeking behavior and cue reinstatement of sucrose-seeking behavior. Locomotion was increased only at the highest RU24969 dose (3 mg/kg). A subsequent experiment demonstrated that the effects of RU24969 (1 mg/kg) on extinguished cocaine-seeking behavior were reversed by the 5-HT1B antagonist GR127935 (3 mg/kg). These findings suggest that the effects of RU24969 on cue and cocaine reinstatement of cocaine-seeking behavior are 5-HT1B receptor-mediated. Overall, the results suggest that stimulation of 5-HT1B receptors may produce a general decrease in motivation.

Original languageEnglish (US)
Pages (from-to)297-307
Number of pages11
JournalPharmacology Biochemistry and Behavior
Volume80
Issue number2
DOIs
StatePublished - Feb 2005

Fingerprint

Receptor, Serotonin, 5-HT1B
Cocaine
Sucrose
Cues
Motivation
Locomotion
Rats
Serotonin 5-HT1 Receptor Antagonists
Reinforcement Schedule
Serotonin
Reinforcement

Keywords

  • 5-HT receptor
  • GR127935
  • Incentive motivation
  • Reinstatement
  • Relapse
  • RU24969

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Stimulation of 5-HT1B receptors decreases cocaine- and sucrose-seeking behavior. / Acosta, Jazmin I.; Boynton, Floren A.; Kirschner, Kenneth F.; Neisewander, Janet.

In: Pharmacology Biochemistry and Behavior, Vol. 80, No. 2, 02.2005, p. 297-307.

Research output: Contribution to journalArticle

Acosta, Jazmin I. ; Boynton, Floren A. ; Kirschner, Kenneth F. ; Neisewander, Janet. / Stimulation of 5-HT1B receptors decreases cocaine- and sucrose-seeking behavior. In: Pharmacology Biochemistry and Behavior. 2005 ; Vol. 80, No. 2. pp. 297-307.
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