Steroids and related natural products-xxvii. Salvia apiana

George Pettit, H. Klinger, Nels Otto N Jorgensen, J. Occolowitz

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Abstract

The pentacyclic triterpene composition of a southern California variety of Salvia apiana (fam. Labiatae) has been assessed. The presence of α-amyrin, oleanolic acid and ursolic acid has been established. Separation of α-amyrin from a closely related impurity believed to be β-amyrin was accomplished by subjecting the mixture to selenium dioxide oxidation and isolating α-amyrin by preparative thin-layer chromatography on silver nitrate-silica gel. Evidence for the presence of isomeric mixtures of two dihydroxy triterpenes and two triterpene aldehydes representing intermediate stages of oxidation from α- and β-amyrin to ursolic and oleanolic acids was presented. Isolation of ursolic acid from a Mexican variety of Salvia karwinskii was also reported.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalPhytochemistry
Volume5
Issue number3
Publication statusPublished - May 1966
Externally publishedYes

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ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Molecular Biology
  • Biochemistry
  • Plant Science

Cite this

Pettit, G., Klinger, H., Jorgensen, N. O. N., & Occolowitz, J. (1966). Steroids and related natural products-xxvii. Salvia apiana. Phytochemistry, 5(3), 301-309.