Steroids and related natural products-XVII. Conversion of lanosterol to 14α-methyl steroids

George Pettit, P. Hofer, W. J. Bowyer, T. R. Kasturi, R. C. Bansal, R. E. Kadunce, B. Green

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The possibility of abnormal steroid biosyntheses leading to in vivo formation of certain 14α-methyl steroids was discussed. In order to further evaluate this proposal, preparation of 14α-methyl steroids related to the androgenic hormones was undertaken. Initially, a thirteen-step degradation sequence was developed for converting isocholesterol (crude lanosterol) to 3-oxo-17β-hydroxy-4,4,14α-trimethyl-5α-androstane.

Original languageEnglish (US)
Pages (from-to)1143-1152
Number of pages10
JournalTetrahedron
Volume19
Issue number7
StatePublished - 1963
Externally publishedYes

Fingerprint

Lanosterol
Biological Products
Steroids
Biosynthesis
Hormones
Degradation

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry

Cite this

Pettit, G., Hofer, P., Bowyer, W. J., Kasturi, T. R., Bansal, R. C., Kadunce, R. E., & Green, B. (1963). Steroids and related natural products-XVII. Conversion of lanosterol to 14α-methyl steroids. Tetrahedron, 19(7), 1143-1152.

Steroids and related natural products-XVII. Conversion of lanosterol to 14α-methyl steroids. / Pettit, George; Hofer, P.; Bowyer, W. J.; Kasturi, T. R.; Bansal, R. C.; Kadunce, R. E.; Green, B.

In: Tetrahedron, Vol. 19, No. 7, 1963, p. 1143-1152.

Research output: Contribution to journalArticle

Pettit, G, Hofer, P, Bowyer, WJ, Kasturi, TR, Bansal, RC, Kadunce, RE & Green, B 1963, 'Steroids and related natural products-XVII. Conversion of lanosterol to 14α-methyl steroids', Tetrahedron, vol. 19, no. 7, pp. 1143-1152.
Pettit G, Hofer P, Bowyer WJ, Kasturi TR, Bansal RC, Kadunce RE et al. Steroids and related natural products-XVII. Conversion of lanosterol to 14α-methyl steroids. Tetrahedron. 1963;19(7):1143-1152.
Pettit, George ; Hofer, P. ; Bowyer, W. J. ; Kasturi, T. R. ; Bansal, R. C. ; Kadunce, R. E. ; Green, B. / Steroids and related natural products-XVII. Conversion of lanosterol to 14α-methyl steroids. In: Tetrahedron. 1963 ; Vol. 19, No. 7. pp. 1143-1152.
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