Stepping into the Next Dimension of Biomaterial Design

Research output: Contribution to journalShort survey

Abstract

Recapitulating the dynamic spatiotemporal behavior of the extracellular matrix using biomaterials is an ongoing challenge. A recent breakthrough by Shadish et al. demonstrates the use of sortase-mediated transpeptidation to site-specifically modify proteins with a range of chemical motifs. Modified proteins were immobilized within biomaterials with high spatiotemporal control and resulted in localized bioactivity.

Original languageEnglish (US)
JournalTrends in Biotechnology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Biocompatible Materials
Biomaterials
Immobilized Proteins
Proteins
Bioactivity
Extracellular Matrix

Keywords

  • biomaterials
  • patterning
  • protein immobilization
  • spatiotemporal control

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Cite this

Stepping into the Next Dimension of Biomaterial Design. / Holloway, Julianne L.

In: Trends in Biotechnology, 01.01.2019.

Research output: Contribution to journalShort survey

@article{3448091a2b4c427481b872f57b50b0e9,
title = "Stepping into the Next Dimension of Biomaterial Design",
abstract = "Recapitulating the dynamic spatiotemporal behavior of the extracellular matrix using biomaterials is an ongoing challenge. A recent breakthrough by Shadish et al. demonstrates the use of sortase-mediated transpeptidation to site-specifically modify proteins with a range of chemical motifs. Modified proteins were immobilized within biomaterials with high spatiotemporal control and resulted in localized bioactivity.",
keywords = "biomaterials, patterning, protein immobilization, spatiotemporal control",
author = "Holloway, {Julianne L.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.tibtech.2019.10.003",
language = "English (US)",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Stepping into the Next Dimension of Biomaterial Design

AU - Holloway, Julianne L.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Recapitulating the dynamic spatiotemporal behavior of the extracellular matrix using biomaterials is an ongoing challenge. A recent breakthrough by Shadish et al. demonstrates the use of sortase-mediated transpeptidation to site-specifically modify proteins with a range of chemical motifs. Modified proteins were immobilized within biomaterials with high spatiotemporal control and resulted in localized bioactivity.

AB - Recapitulating the dynamic spatiotemporal behavior of the extracellular matrix using biomaterials is an ongoing challenge. A recent breakthrough by Shadish et al. demonstrates the use of sortase-mediated transpeptidation to site-specifically modify proteins with a range of chemical motifs. Modified proteins were immobilized within biomaterials with high spatiotemporal control and resulted in localized bioactivity.

KW - biomaterials

KW - patterning

KW - protein immobilization

KW - spatiotemporal control

UR - http://www.scopus.com/inward/record.url?scp=85073991946&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073991946&partnerID=8YFLogxK

U2 - 10.1016/j.tibtech.2019.10.003

DO - 10.1016/j.tibtech.2019.10.003

M3 - Short survey

AN - SCOPUS:85073991946

JO - Trends in Biotechnology

JF - Trends in Biotechnology

SN - 0167-7799

ER -