Stepping into the Next Dimension of Biomaterial Design

Research output: Contribution to journalShort survey

Abstract

Recapitulating the dynamic spatiotemporal behavior of the extracellular matrix using biomaterials is an ongoing challenge. A recent breakthrough by Shadish et al. demonstrates the use of sortase-mediated transpeptidation to site-specifically modify proteins with a range of chemical motifs. Modified proteins were immobilized within biomaterials with high spatiotemporal control and resulted in localized bioactivity.

Original languageEnglish (US)
Pages (from-to)1276-1278
Number of pages3
JournalTrends in Biotechnology
Volume37
Issue number12
DOIs
StatePublished - Dec 2019

Keywords

  • biomaterials
  • patterning
  • protein immobilization
  • spatiotemporal control

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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