Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals

Andrew B. Janowski, Siddharth R. Krishnamurthy, Efrem Lim, Guoyan Zhao, Jason M. Brenchley, Dan H. Barouch, Chrissie Thakwalakwa, Mark J. Manary, Lori R. Holtz, David Wang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Next-generation sequencing has expanded our understanding of the viral populations that constitute the mammalian virome. We describe a novel taxon of viruses named Statoviruses, for Stool associated Tombus-like viruses, present in multiple metagenomic datasets. These viruses define a novel clade that is phylogenetically related to the RNA virus families Tombusviridae and Flaviviridae. Five distinct statovirus types were identified in human, macaque, mouse, and cow gastrointestinal tract samples. The prototype genome, statovirus A, was frequently identified in macaque stool samples from multiple geographically distinct cohorts. Another genome, statovirus C1, was discovered in a stool sample from a human child with fever, cough, and rash. Further experimental data will clarify whether these viruses are infectious to mammals or if they originate from another source present in the mammalian gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)36-44
Number of pages9
JournalVirology
Volume504
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Fingerprint

RNA Viruses
Gastrointestinal Tract
Mammals
Viruses
Macaca
Tombusviridae
Flaviviridae
Genome
Metagenomics
Exanthema
Cough
Fever
Population

Keywords

  • Flaviviridae
  • Statoviruses
  • Tombusviridae
  • Viral discovery
  • Virome

ASJC Scopus subject areas

  • Virology

Cite this

Janowski, A. B., Krishnamurthy, S. R., Lim, E., Zhao, G., Brenchley, J. M., Barouch, D. H., ... Wang, D. (2017). Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. Virology, 504, 36-44. https://doi.org/10.1016/j.virol.2017.01.010

Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. / Janowski, Andrew B.; Krishnamurthy, Siddharth R.; Lim, Efrem; Zhao, Guoyan; Brenchley, Jason M.; Barouch, Dan H.; Thakwalakwa, Chrissie; Manary, Mark J.; Holtz, Lori R.; Wang, David.

In: Virology, Vol. 504, 01.04.2017, p. 36-44.

Research output: Contribution to journalArticle

Janowski, AB, Krishnamurthy, SR, Lim, E, Zhao, G, Brenchley, JM, Barouch, DH, Thakwalakwa, C, Manary, MJ, Holtz, LR & Wang, D 2017, 'Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals', Virology, vol. 504, pp. 36-44. https://doi.org/10.1016/j.virol.2017.01.010
Janowski, Andrew B. ; Krishnamurthy, Siddharth R. ; Lim, Efrem ; Zhao, Guoyan ; Brenchley, Jason M. ; Barouch, Dan H. ; Thakwalakwa, Chrissie ; Manary, Mark J. ; Holtz, Lori R. ; Wang, David. / Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. In: Virology. 2017 ; Vol. 504. pp. 36-44.
@article{62d02e2104224ba885f7723d7cbfd84c,
title = "Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals",
abstract = "Next-generation sequencing has expanded our understanding of the viral populations that constitute the mammalian virome. We describe a novel taxon of viruses named Statoviruses, for Stool associated Tombus-like viruses, present in multiple metagenomic datasets. These viruses define a novel clade that is phylogenetically related to the RNA virus families Tombusviridae and Flaviviridae. Five distinct statovirus types were identified in human, macaque, mouse, and cow gastrointestinal tract samples. The prototype genome, statovirus A, was frequently identified in macaque stool samples from multiple geographically distinct cohorts. Another genome, statovirus C1, was discovered in a stool sample from a human child with fever, cough, and rash. Further experimental data will clarify whether these viruses are infectious to mammals or if they originate from another source present in the mammalian gastrointestinal tract.",
keywords = "Flaviviridae, Statoviruses, Tombusviridae, Viral discovery, Virome",
author = "Janowski, {Andrew B.} and Krishnamurthy, {Siddharth R.} and Efrem Lim and Guoyan Zhao and Brenchley, {Jason M.} and Barouch, {Dan H.} and Chrissie Thakwalakwa and Manary, {Mark J.} and Holtz, {Lori R.} and David Wang",
year = "2017",
month = "4",
day = "1",
doi = "10.1016/j.virol.2017.01.010",
language = "English (US)",
volume = "504",
pages = "36--44",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals

AU - Janowski, Andrew B.

AU - Krishnamurthy, Siddharth R.

AU - Lim, Efrem

AU - Zhao, Guoyan

AU - Brenchley, Jason M.

AU - Barouch, Dan H.

AU - Thakwalakwa, Chrissie

AU - Manary, Mark J.

AU - Holtz, Lori R.

AU - Wang, David

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Next-generation sequencing has expanded our understanding of the viral populations that constitute the mammalian virome. We describe a novel taxon of viruses named Statoviruses, for Stool associated Tombus-like viruses, present in multiple metagenomic datasets. These viruses define a novel clade that is phylogenetically related to the RNA virus families Tombusviridae and Flaviviridae. Five distinct statovirus types were identified in human, macaque, mouse, and cow gastrointestinal tract samples. The prototype genome, statovirus A, was frequently identified in macaque stool samples from multiple geographically distinct cohorts. Another genome, statovirus C1, was discovered in a stool sample from a human child with fever, cough, and rash. Further experimental data will clarify whether these viruses are infectious to mammals or if they originate from another source present in the mammalian gastrointestinal tract.

AB - Next-generation sequencing has expanded our understanding of the viral populations that constitute the mammalian virome. We describe a novel taxon of viruses named Statoviruses, for Stool associated Tombus-like viruses, present in multiple metagenomic datasets. These viruses define a novel clade that is phylogenetically related to the RNA virus families Tombusviridae and Flaviviridae. Five distinct statovirus types were identified in human, macaque, mouse, and cow gastrointestinal tract samples. The prototype genome, statovirus A, was frequently identified in macaque stool samples from multiple geographically distinct cohorts. Another genome, statovirus C1, was discovered in a stool sample from a human child with fever, cough, and rash. Further experimental data will clarify whether these viruses are infectious to mammals or if they originate from another source present in the mammalian gastrointestinal tract.

KW - Flaviviridae

KW - Statoviruses

KW - Tombusviridae

KW - Viral discovery

KW - Virome

UR - http://www.scopus.com/inward/record.url?scp=85012307227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012307227&partnerID=8YFLogxK

U2 - 10.1016/j.virol.2017.01.010

DO - 10.1016/j.virol.2017.01.010

M3 - Article

C2 - 28152382

AN - SCOPUS:85012307227

VL - 504

SP - 36

EP - 44

JO - Virology

JF - Virology

SN - 0042-6822

ER -