Statistical mechanics model for the dynamics of collective epigenetic histone modification

Hang Zhang, Xiao Jun Tian, Abhishek Mukhopadhyay, K. S. Kim, Jianhua Xing

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes.

Original languageEnglish (US)
Article number068101
JournalPhysical Review Letters
Volume112
Issue number6
DOIs
StatePublished - Feb 10 2014
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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