Statistical analysis of relative pose of the thalamus in preterm neonates

Yi Lao, Jie Shi, Yalin Wang, Rafeal Ceschin, Darryl Hwang, M. D. Nelson, Ashok Panigrahy, Natasha Leporé

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Preterm neonates are at higher risk of neurocognitive and neurosensory abnormalities. While numerous studies have looked at the effect of prematurity on brain anatomy, none to date have attempted to understand the relative pose of subcortical structures and to assess its potential as a biomarker of abnormal growth. Here, we perform the first relative pose analysis on a point distribution model (PDM) of the thalamus between 17 preterm and 19 term-born healthy neonates. Initially, linear registration and constrained harmonic registration were computed to remove the irrelevant global pose information and obtain correspondence in vertices. All the parameters for the relative pose were then obtained through similarity transformation. Subsequently, all the pose parameters (scale, rotation and translation) were projected into a log-Euclidean space, where univariate and multivariate statistics were performed. Our method detected relative pose differences in the preterm birth for the left thalamus. Our results suggest that relative pose in subcortical structures is a useful indicator of brain injury, particularly along the anterior surface and the posterior surface. Our study supports the concept that there are regional thalamic asymmetries in the preterm that may be related to subtle white matter injury, have prognostic significance, or be related to preterm birth itself.

Original languageEnglish (US)
Title of host publicationClinical Image-Based Procedures
Subtitle of host publicationTranslational Research in Medical Imaging - Second International Workshop, CLIP 2013, Held in Conjunction with MICCAI 2013, Revised Selected Papers
PublisherSpringer Verlag
Pages1-9
Number of pages9
ISBN (Print)9783319056654
DOIs
StatePublished - 2014
Event2nd International Workshop on Clinical Image-Based Procedures: Translational Research in Medical Imaging, CLIP 2013 - Held in Conjunction with MICCAI 2013 - Nagoya, Japan
Duration: Sep 22 2013Sep 22 2013

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8361 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other2nd International Workshop on Clinical Image-Based Procedures: Translational Research in Medical Imaging, CLIP 2013 - Held in Conjunction with MICCAI 2013
CountryJapan
CityNagoya
Period9/22/139/22/13

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Lao, Y., Shi, J., Wang, Y., Ceschin, R., Hwang, D., Nelson, M. D., Panigrahy, A., & Leporé, N. (2014). Statistical analysis of relative pose of the thalamus in preterm neonates. In Clinical Image-Based Procedures: Translational Research in Medical Imaging - Second International Workshop, CLIP 2013, Held in Conjunction with MICCAI 2013, Revised Selected Papers (pp. 1-9). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 8361 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-319-05666-1_1