Staging of rectal cancer and the pathologist's role in assessing the quality of rectal cancer surgery

Research output: Contribution to journalArticle

Abstract

For rectal cancer, local recurrence following surgical treatment is a grave complication that occurs in as many as 25% of cases. Pathological examination of the surgical resection specimen plays a primary role in assessing both the surgery- and tumor-related factors that contribute to the risk of recurrence. Tumor stage is considered the most accurate indicator of outcome in rectal cancer overall, but additional pathologic features that have been shown to have stage-independent prognostic significance include tumor grade; histologic type; extent of extramural penetration by tumor; neural, venous, and/or lymphatic invasion; tumor border configuration; and host lymphoid response. The most powerful predictor of local recurrence and overall outcome in rectal cancer, however, is the macroscopic quality of the mesorectum in the resection specimen and the proximity of the tumor to the circumferential (radial) resection margin.

Original languageEnglish (US)
Pages (from-to)7-16
Number of pages10
JournalClinics in Colon and Rectal Surgery
Volume15
Issue number1
StatePublished - 2002
Externally publishedYes

Fingerprint

Rectal Neoplasms
Neoplasms
Recurrence
Pathologists

Keywords

  • Mesorectum
  • Pathology
  • Rectal cancer
  • Staging
  • Tumor

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery

Cite this

@article{57861b5529da4591893511dd8b75e860,
title = "Staging of rectal cancer and the pathologist's role in assessing the quality of rectal cancer surgery",
abstract = "For rectal cancer, local recurrence following surgical treatment is a grave complication that occurs in as many as 25{\%} of cases. Pathological examination of the surgical resection specimen plays a primary role in assessing both the surgery- and tumor-related factors that contribute to the risk of recurrence. Tumor stage is considered the most accurate indicator of outcome in rectal cancer overall, but additional pathologic features that have been shown to have stage-independent prognostic significance include tumor grade; histologic type; extent of extramural penetration by tumor; neural, venous, and/or lymphatic invasion; tumor border configuration; and host lymphoid response. The most powerful predictor of local recurrence and overall outcome in rectal cancer, however, is the macroscopic quality of the mesorectum in the resection specimen and the proximity of the tumor to the circumferential (radial) resection margin.",
keywords = "Mesorectum, Pathology, Rectal cancer, Staging, Tumor",
author = "Carolyn Compton",
year = "2002",
language = "English (US)",
volume = "15",
pages = "7--16",
journal = "Clinics in Colon and Rectal Surgery",
issn = "1531-0043",
publisher = "Thieme Medical Publishers",
number = "1",

}

TY - JOUR

T1 - Staging of rectal cancer and the pathologist's role in assessing the quality of rectal cancer surgery

AU - Compton, Carolyn

PY - 2002

Y1 - 2002

N2 - For rectal cancer, local recurrence following surgical treatment is a grave complication that occurs in as many as 25% of cases. Pathological examination of the surgical resection specimen plays a primary role in assessing both the surgery- and tumor-related factors that contribute to the risk of recurrence. Tumor stage is considered the most accurate indicator of outcome in rectal cancer overall, but additional pathologic features that have been shown to have stage-independent prognostic significance include tumor grade; histologic type; extent of extramural penetration by tumor; neural, venous, and/or lymphatic invasion; tumor border configuration; and host lymphoid response. The most powerful predictor of local recurrence and overall outcome in rectal cancer, however, is the macroscopic quality of the mesorectum in the resection specimen and the proximity of the tumor to the circumferential (radial) resection margin.

AB - For rectal cancer, local recurrence following surgical treatment is a grave complication that occurs in as many as 25% of cases. Pathological examination of the surgical resection specimen plays a primary role in assessing both the surgery- and tumor-related factors that contribute to the risk of recurrence. Tumor stage is considered the most accurate indicator of outcome in rectal cancer overall, but additional pathologic features that have been shown to have stage-independent prognostic significance include tumor grade; histologic type; extent of extramural penetration by tumor; neural, venous, and/or lymphatic invasion; tumor border configuration; and host lymphoid response. The most powerful predictor of local recurrence and overall outcome in rectal cancer, however, is the macroscopic quality of the mesorectum in the resection specimen and the proximity of the tumor to the circumferential (radial) resection margin.

KW - Mesorectum

KW - Pathology

KW - Rectal cancer

KW - Staging

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=0036207278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036207278&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0036207278

VL - 15

SP - 7

EP - 16

JO - Clinics in Colon and Rectal Surgery

JF - Clinics in Colon and Rectal Surgery

SN - 1531-0043

IS - 1

ER -