TY - JOUR
T1 - Stability of neuron number in cortical barrels of aging mice
AU - Curcio, C. A.
AU - Coleman, P. D.
PY - 1982/12/1
Y1 - 1982/12/1
N2 - The question of whether age‐related neuron loss occurs in the cerebral cortex of rodents, as it apparently does in humans, has not been directly answered by previous studies. The barrel, a discrete morphological and functional unit in rodent somatosensory cortex, is a favorable system in which to address the problem of neuron loss during senescence. The numerical density and absolute number of neurons as well as barrel volume were determined from a computer‐assisted three‐dimensional reconstruction of thick (100 μm) and semithin (1 μm) sections through a single barrel, C3, from inbred mice (C57Bl/6NNia) at 4, 12, 22, 26, 30, and 33 months of age. The number and density of neuron and glial cells and the volume of the barrel did not change significantly with age. These data indicate that neuron loss is not a universal phenomenon in senescence and that there may be significant species differences in the aging of laboratory rodents and humans.
AB - The question of whether age‐related neuron loss occurs in the cerebral cortex of rodents, as it apparently does in humans, has not been directly answered by previous studies. The barrel, a discrete morphological and functional unit in rodent somatosensory cortex, is a favorable system in which to address the problem of neuron loss during senescence. The numerical density and absolute number of neurons as well as barrel volume were determined from a computer‐assisted three‐dimensional reconstruction of thick (100 μm) and semithin (1 μm) sections through a single barrel, C3, from inbred mice (C57Bl/6NNia) at 4, 12, 22, 26, 30, and 33 months of age. The number and density of neuron and glial cells and the volume of the barrel did not change significantly with age. These data indicate that neuron loss is not a universal phenomenon in senescence and that there may be significant species differences in the aging of laboratory rodents and humans.
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U2 - 10.1002/cne.902120206
DO - 10.1002/cne.902120206
M3 - Article
C2 - 7187916
AN - SCOPUS:0020444124
SN - 0021-9967
VL - 212
SP - 158
EP - 172
JO - Journal of Comparative Neurology
JF - Journal of Comparative Neurology
IS - 2
ER -