TY - JOUR
T1 - Splenic lymphoma
T2 - Ferrite-enhanced MR imaging in rats
AU - Weissleder, R.
AU - Stark, D. D.
AU - Rummeny, E. J.
AU - Compton, C. C.
AU - Ferrucci, J. T.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - Ferrite, a new magnetic resonance (MR) contrast agent, was evaluated in the detection and diagnosis of splenic lymphoma. Before administration of ferrite, normal rat spleens and spleens with diffuse lymphoma showed similar in vitro relaxation times and in vivo MR imaging signal-to-noise ratios (S/N). After the administration of ferrite (50 μmol Fe/kg), the T2 time of lymphomatous spleen was 27.0 msec ± 2.9 (mean ± standard deviation), which was significantly greater than that of normal spleen (10.7 msec ± 1.5, P < .005). The S/N of ferrite-enhanced in vivo MR images of lymphomatous spleen was 12.4 ± 0.9, which was significantly greater than normal (5.7 ± 0.2, P < .005). Similar experiments with animal models of micronodular lymphoma also demonstrated that ferrite-enhanced MR imaging can distinguish micronodular lymphoma from normal spleen. Benign splenomegaly, studied with an animal model of erythroid hyperplasia, showed ferrite-enhanced MR tissue characteristics that were indistinguishable from those of normal spleen.
AB - Ferrite, a new magnetic resonance (MR) contrast agent, was evaluated in the detection and diagnosis of splenic lymphoma. Before administration of ferrite, normal rat spleens and spleens with diffuse lymphoma showed similar in vitro relaxation times and in vivo MR imaging signal-to-noise ratios (S/N). After the administration of ferrite (50 μmol Fe/kg), the T2 time of lymphomatous spleen was 27.0 msec ± 2.9 (mean ± standard deviation), which was significantly greater than that of normal spleen (10.7 msec ± 1.5, P < .005). The S/N of ferrite-enhanced in vivo MR images of lymphomatous spleen was 12.4 ± 0.9, which was significantly greater than normal (5.7 ± 0.2, P < .005). Similar experiments with animal models of micronodular lymphoma also demonstrated that ferrite-enhanced MR imaging can distinguish micronodular lymphoma from normal spleen. Benign splenomegaly, studied with an animal model of erythroid hyperplasia, showed ferrite-enhanced MR tissue characteristics that were indistinguishable from those of normal spleen.
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U2 - 10.1148/radiology.166.2.3336717
DO - 10.1148/radiology.166.2.3336717
M3 - Article
C2 - 3336717
AN - SCOPUS:0023906951
SN - 0033-8419
VL - 166
SP - 423
EP - 430
JO - Radiology
JF - Radiology
IS - 2
ER -