Specific parental depression symptoms as risk markers for new-onset depression in high-risk offspring

Becky Mars, Gordon T. Harold, Kit Elam, Ruth Sellers, Michael J. Owen, Nicholas Craddock, Ajay K. Thapar, Frances Rice, Stephan Collishaw, Anita Thapar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To disaggregate the depression construct and investigate whether specific depression symptoms in parents with a history of recurrent depression are clinical risk markers for future depression in their high-risk offspring. Our hypothesis was that parental symptoms of the type that might impact offspring would most likely be of greatest importance. Method: Data were drawn from a longitudinal highrisk family study. Families were mainly recruited from primary care and included 337 parent-child dyads. Parents had a history of recurrent DSM-IV unipolar depression and were aged 26-55 years. Their offspring (197 female and 140 male) were aged 9-17 years. Three assessments were conducted between April 2007 and April 2011. Ninety-one percent of families (n = 305) provided full interview data at baseline and at least 1 follow-up, of which 291 were included in the primary analysis. The main outcome measure was new-onset DSM-IV mood disorder in the offspring, which was assessed using the Child and Adolescent Psychiatric Assessment. Results: Of the 9 DSM-IV depression symptoms, parental change in appetite or weight, specifically loss of appetite or weight, most strongly predicted newonset mood disorder (odds ratio [OR] = 4.47; 95% CI, 2.04-9.79; P <.001) and future depression symptoms in the offspring (β = 0.12; B = 0.21; 95% CI, 0.00-0.42; P = .050). The cross-generational association was not accounted for by measures of parental depression severity (total depression symptom score, episode recurrence, age at onset, and past impairment or hospitalization) or other potential confounds (parent physical health, eating disorder, or medication). Conclusions: Findings from this study suggest that loss of appetite or weight in parents with a history of recurrent depression is a marker of risk for depression in their offspring. The findings highlight the importance of examining depression heterogeneity. The biological and environmental mechanisms underlying this finding require investigation.

Original languageEnglish (US)
Pages (from-to)925-931
Number of pages7
JournalJournal of Clinical Psychiatry
Volume74
Issue number9
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Depression
Appetite
Diagnostic and Statistical Manual of Mental Disorders
Parents
Mood Disorders
Adolescent Psychiatry
Weights and Measures
Child Psychiatry
Depressive Disorder
Age of Onset
Weight Loss
Primary Health Care
Hospitalization
Biomarkers
Odds Ratio
Outcome Assessment (Health Care)
Interviews
Recurrence
Health

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Mars, B., Harold, G. T., Elam, K., Sellers, R., Owen, M. J., Craddock, N., ... Thapar, A. (2013). Specific parental depression symptoms as risk markers for new-onset depression in high-risk offspring. Journal of Clinical Psychiatry, 74(9), 925-931. https://doi.org/10.4088/JCP.12m08152

Specific parental depression symptoms as risk markers for new-onset depression in high-risk offspring. / Mars, Becky; Harold, Gordon T.; Elam, Kit; Sellers, Ruth; Owen, Michael J.; Craddock, Nicholas; Thapar, Ajay K.; Rice, Frances; Collishaw, Stephan; Thapar, Anita.

In: Journal of Clinical Psychiatry, Vol. 74, No. 9, 2013, p. 925-931.

Research output: Contribution to journalArticle

Mars, B, Harold, GT, Elam, K, Sellers, R, Owen, MJ, Craddock, N, Thapar, AK, Rice, F, Collishaw, S & Thapar, A 2013, 'Specific parental depression symptoms as risk markers for new-onset depression in high-risk offspring', Journal of Clinical Psychiatry, vol. 74, no. 9, pp. 925-931. https://doi.org/10.4088/JCP.12m08152
Mars, Becky ; Harold, Gordon T. ; Elam, Kit ; Sellers, Ruth ; Owen, Michael J. ; Craddock, Nicholas ; Thapar, Ajay K. ; Rice, Frances ; Collishaw, Stephan ; Thapar, Anita. / Specific parental depression symptoms as risk markers for new-onset depression in high-risk offspring. In: Journal of Clinical Psychiatry. 2013 ; Vol. 74, No. 9. pp. 925-931.
@article{ef03d1c674b54f0393d478e9f03d467a,
title = "Specific parental depression symptoms as risk markers for new-onset depression in high-risk offspring",
abstract = "Objective: To disaggregate the depression construct and investigate whether specific depression symptoms in parents with a history of recurrent depression are clinical risk markers for future depression in their high-risk offspring. Our hypothesis was that parental symptoms of the type that might impact offspring would most likely be of greatest importance. Method: Data were drawn from a longitudinal highrisk family study. Families were mainly recruited from primary care and included 337 parent-child dyads. Parents had a history of recurrent DSM-IV unipolar depression and were aged 26-55 years. Their offspring (197 female and 140 male) were aged 9-17 years. Three assessments were conducted between April 2007 and April 2011. Ninety-one percent of families (n = 305) provided full interview data at baseline and at least 1 follow-up, of which 291 were included in the primary analysis. The main outcome measure was new-onset DSM-IV mood disorder in the offspring, which was assessed using the Child and Adolescent Psychiatric Assessment. Results: Of the 9 DSM-IV depression symptoms, parental change in appetite or weight, specifically loss of appetite or weight, most strongly predicted newonset mood disorder (odds ratio [OR] = 4.47; 95{\%} CI, 2.04-9.79; P <.001) and future depression symptoms in the offspring (β = 0.12; B = 0.21; 95{\%} CI, 0.00-0.42; P = .050). The cross-generational association was not accounted for by measures of parental depression severity (total depression symptom score, episode recurrence, age at onset, and past impairment or hospitalization) or other potential confounds (parent physical health, eating disorder, or medication). Conclusions: Findings from this study suggest that loss of appetite or weight in parents with a history of recurrent depression is a marker of risk for depression in their offspring. The findings highlight the importance of examining depression heterogeneity. The biological and environmental mechanisms underlying this finding require investigation.",
author = "Becky Mars and Harold, {Gordon T.} and Kit Elam and Ruth Sellers and Owen, {Michael J.} and Nicholas Craddock and Thapar, {Ajay K.} and Frances Rice and Stephan Collishaw and Anita Thapar",
year = "2013",
doi = "10.4088/JCP.12m08152",
language = "English (US)",
volume = "74",
pages = "925--931",
journal = "The Journal of clinical psychiatry",
issn = "0160-6689",
publisher = "Physicians Postgraduate Press Inc.",
number = "9",

}

TY - JOUR

T1 - Specific parental depression symptoms as risk markers for new-onset depression in high-risk offspring

AU - Mars, Becky

AU - Harold, Gordon T.

AU - Elam, Kit

AU - Sellers, Ruth

AU - Owen, Michael J.

AU - Craddock, Nicholas

AU - Thapar, Ajay K.

AU - Rice, Frances

AU - Collishaw, Stephan

AU - Thapar, Anita

PY - 2013

Y1 - 2013

N2 - Objective: To disaggregate the depression construct and investigate whether specific depression symptoms in parents with a history of recurrent depression are clinical risk markers for future depression in their high-risk offspring. Our hypothesis was that parental symptoms of the type that might impact offspring would most likely be of greatest importance. Method: Data were drawn from a longitudinal highrisk family study. Families were mainly recruited from primary care and included 337 parent-child dyads. Parents had a history of recurrent DSM-IV unipolar depression and were aged 26-55 years. Their offspring (197 female and 140 male) were aged 9-17 years. Three assessments were conducted between April 2007 and April 2011. Ninety-one percent of families (n = 305) provided full interview data at baseline and at least 1 follow-up, of which 291 were included in the primary analysis. The main outcome measure was new-onset DSM-IV mood disorder in the offspring, which was assessed using the Child and Adolescent Psychiatric Assessment. Results: Of the 9 DSM-IV depression symptoms, parental change in appetite or weight, specifically loss of appetite or weight, most strongly predicted newonset mood disorder (odds ratio [OR] = 4.47; 95% CI, 2.04-9.79; P <.001) and future depression symptoms in the offspring (β = 0.12; B = 0.21; 95% CI, 0.00-0.42; P = .050). The cross-generational association was not accounted for by measures of parental depression severity (total depression symptom score, episode recurrence, age at onset, and past impairment or hospitalization) or other potential confounds (parent physical health, eating disorder, or medication). Conclusions: Findings from this study suggest that loss of appetite or weight in parents with a history of recurrent depression is a marker of risk for depression in their offspring. The findings highlight the importance of examining depression heterogeneity. The biological and environmental mechanisms underlying this finding require investigation.

AB - Objective: To disaggregate the depression construct and investigate whether specific depression symptoms in parents with a history of recurrent depression are clinical risk markers for future depression in their high-risk offspring. Our hypothesis was that parental symptoms of the type that might impact offspring would most likely be of greatest importance. Method: Data were drawn from a longitudinal highrisk family study. Families were mainly recruited from primary care and included 337 parent-child dyads. Parents had a history of recurrent DSM-IV unipolar depression and were aged 26-55 years. Their offspring (197 female and 140 male) were aged 9-17 years. Three assessments were conducted between April 2007 and April 2011. Ninety-one percent of families (n = 305) provided full interview data at baseline and at least 1 follow-up, of which 291 were included in the primary analysis. The main outcome measure was new-onset DSM-IV mood disorder in the offspring, which was assessed using the Child and Adolescent Psychiatric Assessment. Results: Of the 9 DSM-IV depression symptoms, parental change in appetite or weight, specifically loss of appetite or weight, most strongly predicted newonset mood disorder (odds ratio [OR] = 4.47; 95% CI, 2.04-9.79; P <.001) and future depression symptoms in the offspring (β = 0.12; B = 0.21; 95% CI, 0.00-0.42; P = .050). The cross-generational association was not accounted for by measures of parental depression severity (total depression symptom score, episode recurrence, age at onset, and past impairment or hospitalization) or other potential confounds (parent physical health, eating disorder, or medication). Conclusions: Findings from this study suggest that loss of appetite or weight in parents with a history of recurrent depression is a marker of risk for depression in their offspring. The findings highlight the importance of examining depression heterogeneity. The biological and environmental mechanisms underlying this finding require investigation.

UR - http://www.scopus.com/inward/record.url?scp=84884807881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884807881&partnerID=8YFLogxK

U2 - 10.4088/JCP.12m08152

DO - 10.4088/JCP.12m08152

M3 - Article

C2 - 24107766

AN - SCOPUS:84884807881

VL - 74

SP - 925

EP - 931

JO - The Journal of clinical psychiatry

JF - The Journal of clinical psychiatry

SN - 0160-6689

IS - 9

ER -