6 Citations (Scopus)

Abstract

Controlled release formulations for local, in vivo drug delivery are of growing interest to device manufacturers, research scientists, and clinicians; however, most research characterizing controlled release formulations occurs in vitro because the spatial and temporal distribution of drug delivery is difficult to measure in vivo. In this work, in vivo magnetic resonance imaging (MRI) of local drug delivery was performed to visualize and quantify the time resolved distribution of MRI contrast agents. Three-dimensional T 1 maps (generated from T 1 -weighted images with varied T R) were processed using noise-reducing filtering. A segmented region of contrast, from a thresholded image, was converted to concentration maps using the equation 1 / T 1 = 1 / T 1, 0 + R 1 C, where T 1, 0 and T 1 are the precontrast and postcontrast T 1 map values, respectively. In this technique, a uniform estimated value for T 1, 0 was used. Error estimations were performed for each step. The practical usefulness of this method was assessed using comparisons between devices located in different locations both with and without contrast. The method using a uniform T 1, 0, requiring no registration of pre- and postcontrast image volumes, was compared to a method using either affine or deformation registrations.

Original languageEnglish (US)
Article number149608
JournalComputational and Mathematical Methods in Medicine
Volume2013
DOIs
StatePublished - 2013

Fingerprint

Drug Delivery
Magnetic Resonance Imaging
Magnetic resonance
Drug delivery
Quantification
Imaging techniques
Registration
Pharmaceutical Preparations
Equipment and Supplies
Formulation
Error Estimation
Research
Error analysis
Contrast Media
Noise
Quantify
Filtering
Three-dimensional

ASJC Scopus subject areas

  • Applied Mathematics
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Spatiotemporal quantification of local drug delivery using MRI. / Giers, Morgan B.; McLaren, Alex C.; Plasencia, Jonathan D.; Frakes, David; McLemore, Ryan; Caplan, Michael.

In: Computational and Mathematical Methods in Medicine, Vol. 2013, 149608, 2013.

Research output: Contribution to journalArticle

Giers, Morgan B. ; McLaren, Alex C. ; Plasencia, Jonathan D. ; Frakes, David ; McLemore, Ryan ; Caplan, Michael. / Spatiotemporal quantification of local drug delivery using MRI. In: Computational and Mathematical Methods in Medicine. 2013 ; Vol. 2013.
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