Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array

Sisi Fan, Bin Ji, Yan Liu, Kexuan Zou, Zhijin Tian, Bin Dai, Daxiang Cui, Pengfei Zhang, Yonggang Ke, Jie Song

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Inspired by efficient biomolecular reactions in the cell, versatile DNA nanostructures have been explored for manipulating the spatial position and regulating reactions at the molecular level. Spatially controlled arrangement of molecules on the artificial scaffolds generally leads to enhanced reaction activities. Especially, the rich toolset of dynamic DNA nanostructures provides a potential route towards more sophisticated and vigorous regulation of molecular reactions. Herein, a reconfigurable DNA origami domino array (DODA) as a dynamic scaffold was adopted in this work for temporal-controlled and switchable molecular cascade reactions. Dynamic regulation of the assembly of G-quadruplex, hybridization of parallel-stranded duplex and assembly of binary DNAzyme were demonstrated. Molecular cascade reactions on the triggered reconfiguration of DODAs were realized, resulting in more complex, dynamic, and switchable control over the reactions.

Original languageEnglish (US)
Article numbere202116324
JournalAngewandte Chemie - International Edition
Issue number9
StatePublished - Feb 21 2022
Externally publishedYes


  • cascade reactions
  • dynamic regulation
  • reconfigurable DNA origami
  • spatial control

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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