Spatially extended forward suppression in primate auditory cortex

Yi Zhou, Xiaoqin Wang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

When auditory neurons are stimulated with a pair of sounds, the preceding sound can inhibit the neural responses to the succeeding sound. This phenomenon, referred to as 'forward suppression', has been linked to perceptual forward masking. Previous studies investigating forward suppression typically measured the interaction between masker and probe sounds using a fixed sound location. However, in natural environments, interacting sounds often come from different spatial locations. The present study investigated two questions regarding forward suppression in the primary auditory cortex and adjacent caudal field of awake marmoset monkeys. First, what is the relationship between the location of a masker and its effectiveness in inhibiting neural response to a probe? Second, does varying the location of a masker change the spectral profile of forward suppression? We found that a masker can inhibit a neuron's response to a probe located at a preferred location even when the masker is located at a non-preferred location of a neuron. This is especially so for neurons in the caudal field. Furthermore, we found that the strongest forward suppression is observed when a masker's frequency is close to the best frequency of a neuron, regardless of the location of the masker. These results reveal, for the first time, the stability of forward masking in cortical processing of multiple sounds presented from different locations. They suggest that forward suppression in the auditory cortex is spectrally specific and spatially broad with respect to the frequency and location of the masker, respectively.

Original languageEnglish (US)
Pages (from-to)919-933
Number of pages15
JournalEuropean Journal of Neuroscience
Volume39
Issue number6
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Auditory Cortex
Primates
Neurons
Perceptual Masking
Callithrix
Haplorhini

Keywords

  • Auditory cortex
  • Forward masking
  • Frequency tuning
  • Spatial selectivity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spatially extended forward suppression in primate auditory cortex. / Zhou, Yi; Wang, Xiaoqin.

In: European Journal of Neuroscience, Vol. 39, No. 6, 2014, p. 919-933.

Research output: Contribution to journalArticle

@article{1515c37ce8bf4d84b38d550e81a493a4,
title = "Spatially extended forward suppression in primate auditory cortex",
abstract = "When auditory neurons are stimulated with a pair of sounds, the preceding sound can inhibit the neural responses to the succeeding sound. This phenomenon, referred to as 'forward suppression', has been linked to perceptual forward masking. Previous studies investigating forward suppression typically measured the interaction between masker and probe sounds using a fixed sound location. However, in natural environments, interacting sounds often come from different spatial locations. The present study investigated two questions regarding forward suppression in the primary auditory cortex and adjacent caudal field of awake marmoset monkeys. First, what is the relationship between the location of a masker and its effectiveness in inhibiting neural response to a probe? Second, does varying the location of a masker change the spectral profile of forward suppression? We found that a masker can inhibit a neuron's response to a probe located at a preferred location even when the masker is located at a non-preferred location of a neuron. This is especially so for neurons in the caudal field. Furthermore, we found that the strongest forward suppression is observed when a masker's frequency is close to the best frequency of a neuron, regardless of the location of the masker. These results reveal, for the first time, the stability of forward masking in cortical processing of multiple sounds presented from different locations. They suggest that forward suppression in the auditory cortex is spectrally specific and spatially broad with respect to the frequency and location of the masker, respectively.",
keywords = "Auditory cortex, Forward masking, Frequency tuning, Spatial selectivity",
author = "Yi Zhou and Xiaoqin Wang",
year = "2014",
doi = "10.1111/ejn.12460",
language = "English (US)",
volume = "39",
pages = "919--933",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Spatially extended forward suppression in primate auditory cortex

AU - Zhou, Yi

AU - Wang, Xiaoqin

PY - 2014

Y1 - 2014

N2 - When auditory neurons are stimulated with a pair of sounds, the preceding sound can inhibit the neural responses to the succeeding sound. This phenomenon, referred to as 'forward suppression', has been linked to perceptual forward masking. Previous studies investigating forward suppression typically measured the interaction between masker and probe sounds using a fixed sound location. However, in natural environments, interacting sounds often come from different spatial locations. The present study investigated two questions regarding forward suppression in the primary auditory cortex and adjacent caudal field of awake marmoset monkeys. First, what is the relationship between the location of a masker and its effectiveness in inhibiting neural response to a probe? Second, does varying the location of a masker change the spectral profile of forward suppression? We found that a masker can inhibit a neuron's response to a probe located at a preferred location even when the masker is located at a non-preferred location of a neuron. This is especially so for neurons in the caudal field. Furthermore, we found that the strongest forward suppression is observed when a masker's frequency is close to the best frequency of a neuron, regardless of the location of the masker. These results reveal, for the first time, the stability of forward masking in cortical processing of multiple sounds presented from different locations. They suggest that forward suppression in the auditory cortex is spectrally specific and spatially broad with respect to the frequency and location of the masker, respectively.

AB - When auditory neurons are stimulated with a pair of sounds, the preceding sound can inhibit the neural responses to the succeeding sound. This phenomenon, referred to as 'forward suppression', has been linked to perceptual forward masking. Previous studies investigating forward suppression typically measured the interaction between masker and probe sounds using a fixed sound location. However, in natural environments, interacting sounds often come from different spatial locations. The present study investigated two questions regarding forward suppression in the primary auditory cortex and adjacent caudal field of awake marmoset monkeys. First, what is the relationship between the location of a masker and its effectiveness in inhibiting neural response to a probe? Second, does varying the location of a masker change the spectral profile of forward suppression? We found that a masker can inhibit a neuron's response to a probe located at a preferred location even when the masker is located at a non-preferred location of a neuron. This is especially so for neurons in the caudal field. Furthermore, we found that the strongest forward suppression is observed when a masker's frequency is close to the best frequency of a neuron, regardless of the location of the masker. These results reveal, for the first time, the stability of forward masking in cortical processing of multiple sounds presented from different locations. They suggest that forward suppression in the auditory cortex is spectrally specific and spatially broad with respect to the frequency and location of the masker, respectively.

KW - Auditory cortex

KW - Forward masking

KW - Frequency tuning

KW - Spatial selectivity

UR - http://www.scopus.com/inward/record.url?scp=84896112789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896112789&partnerID=8YFLogxK

U2 - 10.1111/ejn.12460

DO - 10.1111/ejn.12460

M3 - Article

VL - 39

SP - 919

EP - 933

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 6

ER -