Spatially explicit non-mendelian diploid model

Nicolas Lanchier, C. Neuhauser

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We introduce a spatially explicit model for the competition between type a and type b alleles. Each vertex of the d-dimensional integer lattice is occupied by a diploid individual, which is in one of three possible states or genotypes: aa, ab or bb. We are interested in the long-term behavior of the gene frequencies when Mendel's law of segregation does not hold. This results in a voter type model depending on four parameters; each of these parameters measures the strength of competition between genes during meiosis. We prove that with or without a spatial structure, type a and type b alleles coexist at equilibrium when homozygotes are poor competitors. The inclusion of a spatial structure, however, reduces the parameter region where coexistence occurs.

Original languageEnglish (US)
Pages (from-to)1880-1920
Number of pages41
JournalAnnals of Applied Probability
Volume19
Issue number5
DOIs
StatePublished - Oct 2009

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Spatial Structure
Gene
Vote
Segregation
Genotype
Coexistence
Inclusion
Model
Integer
Vertex of a graph
Spatial structure
Competitors

Keywords

  • Annihilating branching process
  • Non-Mendelian segregation
  • Voter model

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty

Cite this

Spatially explicit non-mendelian diploid model. / Lanchier, Nicolas; Neuhauser, C.

In: Annals of Applied Probability, Vol. 19, No. 5, 10.2009, p. 1880-1920.

Research output: Contribution to journalArticle

Lanchier, Nicolas ; Neuhauser, C. / Spatially explicit non-mendelian diploid model. In: Annals of Applied Probability. 2009 ; Vol. 19, No. 5. pp. 1880-1920.
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