Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures

Rahul Chhabra; Jaswinder Sharma; Yonggang Ke; Yan Liu; Sherri Rinker; Stuart Lindsay; Hao Yan

doi:10.1021/ja072410u

Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures

Rahul Chhabra, Jaswinder Sharma, Yonggang Ke, Yan Liu, Sherri Rinker, Stuart Lindsay, Hao Yan

Research output: Contribution to journal › Article › peer-review

216 Scopus citations

Abstract

Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.

Original language	English (US)
Pages (from-to)	10304-10305
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	34
DOIs	https://doi.org/10.1021/ja072410u
State	Published - Aug 29 2007

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja072410u

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abstract = "Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.",

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AU - Rinker, Sherri

AU - Lindsay, Stuart

AU - Yan, Hao

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