Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats

Heather A. Bimonte, Ann Charlotte E. Granholm, Hyemyung Seo, Ole Isacson

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Using young and aged rats, we investigated relationships between amyloid precursor protein (APP) and working or reference memory, as well as assessed whether cognitive testing altered APP levels. In young rats, higher APP levels were related to more working memory errors as a linear function. Aged rats exhibited a curvilinear relationship between APP and working memory, with moderate APP levels associated with better relative performance. A comparison of rats that received cognitive testing with those that did not showed that testing decreased APP levels in young, but not aged, rats. Collectively, the data suggest that young and aged rats exhibit different relationships between APP and working memory, and that aged rats do not maintain the capacity to decrease APP in response to cognitive testing.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalNeuroscience Letters
Volume328
Issue number1
DOIs
StatePublished - Aug 2 2002
Externally publishedYes

Keywords

  • Aging
  • Amyloid precursor protein
  • Hippocampus
  • Learning
  • Radial arm
  • Working memory

ASJC Scopus subject areas

  • Neuroscience(all)

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