Spatial and temporal organization of ensemble representations for different odor classes in the moth antennal lobe

Hong Lei, Thomas A. Christensen, John G. Hildebrand

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

In the insect antennal lobe, odor discrimination depends on the ability of the brain to read neural activity patterns across arrays of uniquely identifiable olfactory glomeruli. Less is understood about the complex temporal dynamics and interglomerular interactions that underlie these spatial patterns. Using neural-ensemble recording, we show that the evoked firing patterns within and between groups of glomeruli are odor dependent and organized in both space and time. Simultaneous recordings from up to 15 units per ensemble were obtained from four zones of glomerular neuropil in response to four classes of odorants: pheromones, monoterpenoids, aromatics, and aliphatics. Each odor class evoked a different pattern of excitation and inhibition across recording zones. The excitatory response field for each class was spatially defined, but inhibitory activity was spread across the antennal lobe, reflecting a center-surround organization. Some chemically related odorants were not easily distinguished by their spatial patterns, but each odorant evoked transient synchronous firing across a uniquely different subset of ensemble units. Examination of 535 cell pairs revealed a strong relationship between their recording positions, temporal correlations, and similarity of odor response profiles. These findings provide the first definitive support for a nested architecture in the insect olfactory system that uses both spatial and temporal coordination of firing to encode chemosensory signals. The spatial extent of the representation is defined by a stereotyped focus of glomerular activity for each odorant class, whereas the transient temporal correlations embedded within the ensemble provide a second coding dimension that can facilitate discrimination between chemically similar volatiles.

Original languageEnglish (US)
Pages (from-to)11108-11119
Number of pages12
JournalJournal of Neuroscience
Volume24
Issue number49
DOIs
StatePublished - Dec 8 2004
Externally publishedYes

Fingerprint

Moths
Insects
Monoterpenes
Neuropil
Odorants
Olfactory Bulb
Pheromones
Brain

Keywords

  • Ensemble recording
  • Glomerulus
  • Odor discrimination
  • Olfaction
  • Spatiotemporal coding
  • Synchrony

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spatial and temporal organization of ensemble representations for different odor classes in the moth antennal lobe. / Lei, Hong; Christensen, Thomas A.; Hildebrand, John G.

In: Journal of Neuroscience, Vol. 24, No. 49, 08.12.2004, p. 11108-11119.

Research output: Contribution to journalArticle

Lei, Hong ; Christensen, Thomas A. ; Hildebrand, John G. / Spatial and temporal organization of ensemble representations for different odor classes in the moth antennal lobe. In: Journal of Neuroscience. 2004 ; Vol. 24, No. 49. pp. 11108-11119.
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