Spatial ability of XY sex-reversed female mice

Amy Jo Stavnezer; Cary S. McDowell; Lynn A. Hyde; Heather A. Bimonte; Seth A. Balogh; Blair J. Hoplight; Victor H. Denenberg

doi:10.1016/S0166-4328(00)00174-1

Spatial ability of XY sex-reversed female mice

Amy Jo Stavnezer, Cary S. McDowell, Lynn A. Hyde, Heather A. Bimonte, Seth A. Balogh, Blair J. Hoplight, Victor H. Denenberg

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Perinatal gonadal hormones significantly affect subsequent sex differences in reproductive and non-reproductive behaviors in rodents. However, the influence of the sex chromosomes on these behaviors has been largely ignored. To assess the influence of the non-pseudoautosomal region of the Y chromosome, C57BL/JEi male and female mice and mice from the C57BL/6JEi-Y^POS consomic strain were given behavioral tests known to distinguish males from females. The C57BL/6JEi-Y^POStrain contains sex-reversed XY-females which, when compared to their XX-female siblings, allow assessment of the influence of the Y chromosome in a female phenotype. XX-females and XY-females did not differ on open-field activity, the Lashley maze, or active avoidance learning, but XY-females were significantly better than XX-females on the Morris hidden platform spatial maze. These findings suggest that males may have both a genetic and a hormonal mechanism to ensure visuospatial superiority.

Original language	English (US)
Pages (from-to)	135-143
Number of pages	9
Journal	Behavioural Brain Research
Volume	112
Issue number	1-2
DOIs	https://doi.org/10.1016/S0166-4328(00)00174-1
State	Published - 2000
Externally published	Yes

Keywords

Estrogen
Morris maze
Sex difference
Sex reversal
Spatial ability
Testosterone
Y chromosome

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/S0166-4328(00)00174-1

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title = "Spatial ability of XY sex-reversed female mice",

abstract = "Perinatal gonadal hormones significantly affect subsequent sex differences in reproductive and non-reproductive behaviors in rodents. However, the influence of the sex chromosomes on these behaviors has been largely ignored. To assess the influence of the non-pseudoautosomal region of the Y chromosome, C57BL/JEi male and female mice and mice from the C57BL/6JEi-YPOS consomic strain were given behavioral tests known to distinguish males from females. The C57BL/6JEi-YPOStrain contains sex-reversed XY-females which, when compared to their XX-female siblings, allow assessment of the influence of the Y chromosome in a female phenotype. XX-females and XY-females did not differ on open-field activity, the Lashley maze, or active avoidance learning, but XY-females were significantly better than XX-females on the Morris hidden platform spatial maze. These findings suggest that males may have both a genetic and a hormonal mechanism to ensure visuospatial superiority.",

keywords = "Estrogen, Morris maze, Sex difference, Sex reversal, Spatial ability, Testosterone, Y chromosome",

author = "Stavnezer, {Amy Jo} and McDowell, {Cary S.} and Hyde, {Lynn A.} and Bimonte, {Heather A.} and Balogh, {Seth A.} and Hoplight, {Blair J.} and Denenberg, {Victor H.}",

year = "2000",

doi = "10.1016/S0166-4328(00)00174-1",

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AU - Stavnezer, Amy Jo

AU - McDowell, Cary S.

AU - Hyde, Lynn A.

AU - Bimonte, Heather A.

AU - Balogh, Seth A.

AU - Hoplight, Blair J.

AU - Denenberg, Victor H.

PY - 2000

Y1 - 2000

N2 - Perinatal gonadal hormones significantly affect subsequent sex differences in reproductive and non-reproductive behaviors in rodents. However, the influence of the sex chromosomes on these behaviors has been largely ignored. To assess the influence of the non-pseudoautosomal region of the Y chromosome, C57BL/JEi male and female mice and mice from the C57BL/6JEi-YPOS consomic strain were given behavioral tests known to distinguish males from females. The C57BL/6JEi-YPOStrain contains sex-reversed XY-females which, when compared to their XX-female siblings, allow assessment of the influence of the Y chromosome in a female phenotype. XX-females and XY-females did not differ on open-field activity, the Lashley maze, or active avoidance learning, but XY-females were significantly better than XX-females on the Morris hidden platform spatial maze. These findings suggest that males may have both a genetic and a hormonal mechanism to ensure visuospatial superiority.

AB - Perinatal gonadal hormones significantly affect subsequent sex differences in reproductive and non-reproductive behaviors in rodents. However, the influence of the sex chromosomes on these behaviors has been largely ignored. To assess the influence of the non-pseudoautosomal region of the Y chromosome, C57BL/JEi male and female mice and mice from the C57BL/6JEi-YPOS consomic strain were given behavioral tests known to distinguish males from females. The C57BL/6JEi-YPOStrain contains sex-reversed XY-females which, when compared to their XX-female siblings, allow assessment of the influence of the Y chromosome in a female phenotype. XX-females and XY-females did not differ on open-field activity, the Lashley maze, or active avoidance learning, but XY-females were significantly better than XX-females on the Morris hidden platform spatial maze. These findings suggest that males may have both a genetic and a hormonal mechanism to ensure visuospatial superiority.

KW - Estrogen

KW - Morris maze

KW - Sex difference

KW - Sex reversal

KW - Spatial ability

KW - Testosterone

KW - Y chromosome

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Spatial ability of XY sex-reversed female mice

Abstract

Keywords

ASJC Scopus subject areas

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