Spatial ability of XY sex-reversed female mice

Amy Jo Stavnezer, Cary S. McDowell, Lynn A. Hyde, Heather Bimonte-Nelson, Seth A. Balogh, Blair J. Hoplight, Victor H. Denenberg

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Perinatal gonadal hormones significantly affect subsequent sex differences in reproductive and non-reproductive behaviors in rodents. However, the influence of the sex chromosomes on these behaviors has been largely ignored. To assess the influence of the non-pseudoautosomal region of the Y chromosome, C57BL/JEi male and female mice and mice from the C57BL/6JEi-YPOS consomic strain were given behavioral tests known to distinguish males from females. The C57BL/6JEi-YPOStrain contains sex-reversed XY-females which, when compared to their XX-female siblings, allow assessment of the influence of the Y chromosome in a female phenotype. XX-females and XY-females did not differ on open-field activity, the Lashley maze, or active avoidance learning, but XY-females were significantly better than XX-females on the Morris hidden platform spatial maze. These findings suggest that males may have both a genetic and a hormonal mechanism to ensure visuospatial superiority.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
JournalBehavioural Brain Research
Volume112
Issue number1-2
StatePublished - 2000
Externally publishedYes

Fingerprint

Y Chromosome
Avoidance Learning
Gonadal Hormones
Sex Chromosomes
Problem-Based Learning
Inbred C57BL Mouse
Sex Characteristics
Spatial Navigation
Rodentia
Phenotype
XY female 46
Behavior Rating Scale

Keywords

  • Estrogen
  • Morris maze
  • Sex difference
  • Sex reversal
  • Spatial ability
  • Testosterone
  • Y chromosome

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Stavnezer, A. J., McDowell, C. S., Hyde, L. A., Bimonte-Nelson, H., Balogh, S. A., Hoplight, B. J., & Denenberg, V. H. (2000). Spatial ability of XY sex-reversed female mice. Behavioural Brain Research, 112(1-2), 135-143.

Spatial ability of XY sex-reversed female mice. / Stavnezer, Amy Jo; McDowell, Cary S.; Hyde, Lynn A.; Bimonte-Nelson, Heather; Balogh, Seth A.; Hoplight, Blair J.; Denenberg, Victor H.

In: Behavioural Brain Research, Vol. 112, No. 1-2, 2000, p. 135-143.

Research output: Contribution to journalArticle

Stavnezer, AJ, McDowell, CS, Hyde, LA, Bimonte-Nelson, H, Balogh, SA, Hoplight, BJ & Denenberg, VH 2000, 'Spatial ability of XY sex-reversed female mice', Behavioural Brain Research, vol. 112, no. 1-2, pp. 135-143.
Stavnezer AJ, McDowell CS, Hyde LA, Bimonte-Nelson H, Balogh SA, Hoplight BJ et al. Spatial ability of XY sex-reversed female mice. Behavioural Brain Research. 2000;112(1-2):135-143.
Stavnezer, Amy Jo ; McDowell, Cary S. ; Hyde, Lynn A. ; Bimonte-Nelson, Heather ; Balogh, Seth A. ; Hoplight, Blair J. ; Denenberg, Victor H. / Spatial ability of XY sex-reversed female mice. In: Behavioural Brain Research. 2000 ; Vol. 112, No. 1-2. pp. 135-143.
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