Soy isoflavone and ascorbic acid supplementation alone or in combination minimally affect plasma lipid peroxides in healthy postmenopausal women

Andrea M. Hutchins, Imogene E. Mciver, Carol Johnston

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The objective of this study was to assess synergistic antioxidant properties of vitamin C and isoflavones. The design was a placebo-controlled crossover trial: 500 mg vitamin C, 5 mg/kg body weight isoflavones, 500 mg vitamin C plus 5 mg/kg body weight isoflavones, or placebo. Total lipid peroxides, plasma vitamin C, and blood pressure were measured. Eight of 10 healthy postmenopausal women completed the study. A multiple analysis of variance was performed and least-squares difference post-hoc test utilized to determine where differences occurred. Significance was defined as P<.05. There was a significant reduction in total lipid peroxides between baseline and isoflavone treatments (3.22±0.72 vs 2.47±0.82 nmol/mL, P<.05). Mean systolic blood pressure was higher during isoflavone intervention than placebo (117±14 vs 125±15 mm Hg, P=.042). Supplementation with vitamin C and isoflavones did not produce a synergistic antioxidant effect. A slight but significant increase in systolic blood pressure occurred with isoflavone supplementation. A larger study should be conducted to fully explore the potential interactions between these antioxidants.

Original languageEnglish (US)
Pages (from-to)1134-1137
Number of pages4
JournalJournal of the American Dietetic Association
Volume105
Issue number7
DOIs
StatePublished - Jul 1 2005

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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