TY - JOUR
T1 - Soy isoflavone and ascorbic acid supplementation alone or in combination minimally affect plasma lipid peroxides in healthy postmenopausal women
AU - Hutchins, Andrea M.
AU - Mciver, Imogene E.
AU - Johnston, Carol
N1 - Funding Information:
This study was funded by the Sustainable Technologies, Agribusiness and Resource Center, Arizona State University, Mesa.
PY - 2005/7
Y1 - 2005/7
N2 - The objective of this study was to assess synergistic antioxidant properties of vitamin C and isoflavones. The design was a placebo-controlled crossover trial: 500 mg vitamin C, 5 mg/kg body weight isoflavones, 500 mg vitamin C plus 5 mg/kg body weight isoflavones, or placebo. Total lipid peroxides, plasma vitamin C, and blood pressure were measured. Eight of 10 healthy postmenopausal women completed the study. A multiple analysis of variance was performed and least-squares difference post-hoc test utilized to determine where differences occurred. Significance was defined as P<.05. There was a significant reduction in total lipid peroxides between baseline and isoflavone treatments (3.22±0.72 vs 2.47±0.82 nmol/mL, P<.05). Mean systolic blood pressure was higher during isoflavone intervention than placebo (117±14 vs 125±15 mm Hg, P=.042). Supplementation with vitamin C and isoflavones did not produce a synergistic antioxidant effect. A slight but significant increase in systolic blood pressure occurred with isoflavone supplementation. A larger study should be conducted to fully explore the potential interactions between these antioxidants.
AB - The objective of this study was to assess synergistic antioxidant properties of vitamin C and isoflavones. The design was a placebo-controlled crossover trial: 500 mg vitamin C, 5 mg/kg body weight isoflavones, 500 mg vitamin C plus 5 mg/kg body weight isoflavones, or placebo. Total lipid peroxides, plasma vitamin C, and blood pressure were measured. Eight of 10 healthy postmenopausal women completed the study. A multiple analysis of variance was performed and least-squares difference post-hoc test utilized to determine where differences occurred. Significance was defined as P<.05. There was a significant reduction in total lipid peroxides between baseline and isoflavone treatments (3.22±0.72 vs 2.47±0.82 nmol/mL, P<.05). Mean systolic blood pressure was higher during isoflavone intervention than placebo (117±14 vs 125±15 mm Hg, P=.042). Supplementation with vitamin C and isoflavones did not produce a synergistic antioxidant effect. A slight but significant increase in systolic blood pressure occurred with isoflavone supplementation. A larger study should be conducted to fully explore the potential interactions between these antioxidants.
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U2 - 10.1016/j.jada.2005.04.028
DO - 10.1016/j.jada.2005.04.028
M3 - Article
C2 - 15983534
AN - SCOPUS:20744455856
SN - 0002-8223
VL - 105
SP - 1134
EP - 1137
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
IS - 7
ER -