Abstract

#x02010;Nitrosodimethylamine is mutagenic in rodents, a drinking water contaminant, and a byproduct of drinking water disinfection by chloramination. Nitrosodimethylamine precursor identification leads to their control and improved understanding of nitrosodimethylamine formation during chloramination. Mass balances on nitrosodimethylamine precursors were evaluated across solid-phase extraction cartridges and in eluates to select the best combination of solid-phase media and eluent that maximized recovery of nitrosodimethylamine precursors into a solvent amenable to time-of-flight mass spectrometry analysis. After reviewing literature and comparing various solid-phase cartridges and eluent combinations, a method was obtained to efficiently recover nitrosodimethylamine precursors. The approach with the greatest recoveries of nitrosodimethylamine precursors involved cation exchange resin loaded with water samples at pH 3 and eluted with 5% NH4OH in methanol. This indicated that nitrosodimethylamine precursors are amines that protonate at low pH and deprotonate at high pH. Quaternary amines were irreversibly sorbed to the cation exchange cartridge and did not account for a large fraction of precursors. Overall, a median recovery of 82% for nitrosodimethylamine precursors was achieved from 11 surface waters and one wastewater. Applying this method allowed discovery of methadone as a new nitrosodimethylamine precursor in wastewater effluent and drinking water treatment plant intakes.

Original languageEnglish (US)
JournalJournal of Separation Science
DOIs
StateAccepted/In press - 2016

Fingerprint

Dimethylnitrosamine
Potable water
Biological materials
Sorption
Desorption
Recovery
Amines
Ion exchange
Wastewater
Positive ions
Water treatment plants
Disinfection
Surface waters
Mass spectrometry
Byproducts
Drinking Water
Effluents
Methanol
Resins
Impurities

Keywords

  • Disinfection byproducts
  • Fractionation
  • Isolation
  • N-Nitrosodimethylamine
  • Precursors

ASJC Scopus subject areas

  • Analytical Chemistry
  • Filtration and Separation

Cite this

@article{074c79252b53466481110171e570fd3d,
title = "Sorption and desorption of organic matter on solid-phase extraction media to isolate and identify N-nitrosodimethylamine precursors",
abstract = "#x02010;Nitrosodimethylamine is mutagenic in rodents, a drinking water contaminant, and a byproduct of drinking water disinfection by chloramination. Nitrosodimethylamine precursor identification leads to their control and improved understanding of nitrosodimethylamine formation during chloramination. Mass balances on nitrosodimethylamine precursors were evaluated across solid-phase extraction cartridges and in eluates to select the best combination of solid-phase media and eluent that maximized recovery of nitrosodimethylamine precursors into a solvent amenable to time-of-flight mass spectrometry analysis. After reviewing literature and comparing various solid-phase cartridges and eluent combinations, a method was obtained to efficiently recover nitrosodimethylamine precursors. The approach with the greatest recoveries of nitrosodimethylamine precursors involved cation exchange resin loaded with water samples at pH 3 and eluted with 5{\%} NH4OH in methanol. This indicated that nitrosodimethylamine precursors are amines that protonate at low pH and deprotonate at high pH. Quaternary amines were irreversibly sorbed to the cation exchange cartridge and did not account for a large fraction of precursors. Overall, a median recovery of 82{\%} for nitrosodimethylamine precursors was achieved from 11 surface waters and one wastewater. Applying this method allowed discovery of methadone as a new nitrosodimethylamine precursor in wastewater effluent and drinking water treatment plant intakes.",
keywords = "Disinfection byproducts, Fractionation, Isolation, N-Nitrosodimethylamine, Precursors",
author = "David Hanigan and Xiaobin Liao and Jinwei Zhang and Pierre Herckes and Paul Westerhoff",
year = "2016",
doi = "10.1002/jssc.201600139",
language = "English (US)",
journal = "Journal of Separation Science",
issn = "1615-9306",
publisher = "Wiley-VCH Verlag",

}

TY - JOUR

T1 - Sorption and desorption of organic matter on solid-phase extraction media to isolate and identify N-nitrosodimethylamine precursors

AU - Hanigan, David

AU - Liao, Xiaobin

AU - Zhang, Jinwei

AU - Herckes, Pierre

AU - Westerhoff, Paul

PY - 2016

Y1 - 2016

N2 - #x02010;Nitrosodimethylamine is mutagenic in rodents, a drinking water contaminant, and a byproduct of drinking water disinfection by chloramination. Nitrosodimethylamine precursor identification leads to their control and improved understanding of nitrosodimethylamine formation during chloramination. Mass balances on nitrosodimethylamine precursors were evaluated across solid-phase extraction cartridges and in eluates to select the best combination of solid-phase media and eluent that maximized recovery of nitrosodimethylamine precursors into a solvent amenable to time-of-flight mass spectrometry analysis. After reviewing literature and comparing various solid-phase cartridges and eluent combinations, a method was obtained to efficiently recover nitrosodimethylamine precursors. The approach with the greatest recoveries of nitrosodimethylamine precursors involved cation exchange resin loaded with water samples at pH 3 and eluted with 5% NH4OH in methanol. This indicated that nitrosodimethylamine precursors are amines that protonate at low pH and deprotonate at high pH. Quaternary amines were irreversibly sorbed to the cation exchange cartridge and did not account for a large fraction of precursors. Overall, a median recovery of 82% for nitrosodimethylamine precursors was achieved from 11 surface waters and one wastewater. Applying this method allowed discovery of methadone as a new nitrosodimethylamine precursor in wastewater effluent and drinking water treatment plant intakes.

AB - #x02010;Nitrosodimethylamine is mutagenic in rodents, a drinking water contaminant, and a byproduct of drinking water disinfection by chloramination. Nitrosodimethylamine precursor identification leads to their control and improved understanding of nitrosodimethylamine formation during chloramination. Mass balances on nitrosodimethylamine precursors were evaluated across solid-phase extraction cartridges and in eluates to select the best combination of solid-phase media and eluent that maximized recovery of nitrosodimethylamine precursors into a solvent amenable to time-of-flight mass spectrometry analysis. After reviewing literature and comparing various solid-phase cartridges and eluent combinations, a method was obtained to efficiently recover nitrosodimethylamine precursors. The approach with the greatest recoveries of nitrosodimethylamine precursors involved cation exchange resin loaded with water samples at pH 3 and eluted with 5% NH4OH in methanol. This indicated that nitrosodimethylamine precursors are amines that protonate at low pH and deprotonate at high pH. Quaternary amines were irreversibly sorbed to the cation exchange cartridge and did not account for a large fraction of precursors. Overall, a median recovery of 82% for nitrosodimethylamine precursors was achieved from 11 surface waters and one wastewater. Applying this method allowed discovery of methadone as a new nitrosodimethylamine precursor in wastewater effluent and drinking water treatment plant intakes.

KW - Disinfection byproducts

KW - Fractionation

KW - Isolation

KW - N-Nitrosodimethylamine

KW - Precursors

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