Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions

Mijeong Kang; Ben Heuberger; John C. Chaput; Christopher Switzer; Juli Feigon

doi:10.1002/anie.201203459

Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)₄T) in the presence of Cs⁺ ions

Mijeong Kang, Ben Heuberger, John C. Chaput, Christopher Switzer, Juli Feigon

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs⁺ ions were found to stabilize a pentaplex of d(T(iG) ₄T). Solution NMR studies of this pentaplex in the presence of Cs⁺ ions (or Na⁺, K⁺, Rb⁺, or NH₄⁺ cations) demonstrate its stability and structure (see picture).

Original language	English (US)
Pages (from-to)	7952-7955
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	32
DOIs	https://doi.org/10.1002/anie.201203459
State	Published - Aug 6 2012

Keywords

DNA structures
NMR spectroscopy
isoguanines
pentaplexes
self-assembled DNA

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201203459

Cite this

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abstract = "What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs+ ions were found to stabilize a pentaplex of d(T(iG) 4T). Solution NMR studies of this pentaplex in the presence of Cs+ ions (or Na+, K+, Rb+, or NH4+ cations) demonstrate its stability and structure (see picture).",

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AU - Heuberger, Ben

AU - Chaput, John C.

AU - Switzer, Christopher

AU - Feigon, Juli

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AB - What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs+ ions were found to stabilize a pentaplex of d(T(iG) 4T). Solution NMR studies of this pentaplex in the presence of Cs+ ions (or Na+, K+, Rb+, or NH4+ cations) demonstrate its stability and structure (see picture).

KW - DNA structures

KW - NMR spectroscopy

KW - isoguanines

KW - pentaplexes

KW - self-assembled DNA

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Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)₄T) in the presence of Cs⁺ ions

Abstract

Keywords

ASJC Scopus subject areas

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