Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions

Mijeong Kang, Ben Heuberger, John C. Chaput, Christopher Switzer, Juli Feigon

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs+ ions were found to stabilize a pentaplex of d(T(iG) 4T). Solution NMR studies of this pentaplex in the presence of Cs+ ions (or Na+, K+, Rb+, or NH4+ cations) demonstrate its stability and structure (see picture).

Original languageEnglish (US)
Pages (from-to)7952-7955
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number32
DOIs
StatePublished - Aug 6 2012

Keywords

  • DNA structures
  • NMR spectroscopy
  • isoguanines
  • pentaplexes
  • self-assembled DNA

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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