Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions

Mijeong Kang, Ben Heuberger, John C. Chaput, Christopher Switzer, Juli Feigon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs+ ions were found to stabilize a pentaplex of d(T(iG) 4T). Solution NMR studies of this pentaplex in the presence of Cs+ ions (or Na+, K+, Rb+, or NH4 + cations) demonstrate its stability and structure (see picture).

Original languageEnglish (US)
Pages (from-to)7952-7955
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number32
DOIs
StatePublished - Aug 6 2012

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DNA
Positive ions
Ions
Cations
Alkali metals
Isomers
Alkali Metals
Nuclear magnetic resonance
Guanine
isoguanine

Keywords

  • DNA structures
  • isoguanines
  • NMR spectroscopy
  • pentaplexes
  • self-assembled DNA

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions. / Kang, Mijeong; Heuberger, Ben; Chaput, John C.; Switzer, Christopher; Feigon, Juli.

In: Angewandte Chemie - International Edition, Vol. 51, No. 32, 06.08.2012, p. 7952-7955.

Research output: Contribution to journalArticle

Kang, Mijeong ; Heuberger, Ben ; Chaput, John C. ; Switzer, Christopher ; Feigon, Juli. / Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 32. pp. 7952-7955.
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