Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions

Mijeong Kang; Ben Heuberger; John C. Chaput; Christopher Switzer; Juli Feigon

doi:10.1002/anie.201203459

Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)₄T) in the presence of Cs⁺ ions

Mijeong Kang, Ben Heuberger, John C. Chaput, Christopher Switzer, Juli Feigon

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs⁺ ions were found to stabilize a pentaplex of d(T(iG) ₄T). Solution NMR studies of this pentaplex in the presence of Cs⁺ ions (or Na⁺, K⁺, Rb⁺, or NH₄⁺ cations) demonstrate its stability and structure (see picture).

Original language	English (US)
Pages (from-to)	7952-7955
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	32
DOIs	https://doi.org/10.1002/anie.201203459
State	Published - Aug 6 2012

Keywords

DNA structures
NMR spectroscopy
isoguanines
pentaplexes
self-assembled DNA

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201203459

Cite this

@article{b77648d32ac94a42aa94c8c398ad05b3,

title = "Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions",

abstract = "What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs+ ions were found to stabilize a pentaplex of d(T(iG) 4T). Solution NMR studies of this pentaplex in the presence of Cs+ ions (or Na+, K+, Rb+, or NH4+ cations) demonstrate its stability and structure (see picture).",

keywords = "DNA structures, NMR spectroscopy, isoguanines, pentaplexes, self-assembled DNA",

author = "Mijeong Kang and Ben Heuberger and Chaput, {John C.} and Christopher Switzer and Juli Feigon",

year = "2012",

month = aug,

day = "6",

doi = "10.1002/anie.201203459",

language = "English (US)",

volume = "51",

pages = "7952--7955",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "32",

}

TY - JOUR

T1 - Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions

AU - Kang, Mijeong

AU - Heuberger, Ben

AU - Chaput, John C.

AU - Switzer, Christopher

AU - Feigon, Juli

PY - 2012/8/6

Y1 - 2012/8/6

N2 - What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs+ ions were found to stabilize a pentaplex of d(T(iG) 4T). Solution NMR studies of this pentaplex in the presence of Cs+ ions (or Na+, K+, Rb+, or NH4+ cations) demonstrate its stability and structure (see picture).

AB - What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs+ ions were found to stabilize a pentaplex of d(T(iG) 4T). Solution NMR studies of this pentaplex in the presence of Cs+ ions (or Na+, K+, Rb+, or NH4+ cations) demonstrate its stability and structure (see picture).

KW - DNA structures

KW - NMR spectroscopy

KW - isoguanines

KW - pentaplexes

KW - self-assembled DNA

UR - http://www.scopus.com/inward/record.url?scp=84864750910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864750910&partnerID=8YFLogxK

U2 - 10.1002/anie.201203459

DO - 10.1002/anie.201203459

M3 - Article

C2 - 22767484

AN - SCOPUS:84864750910

SN - 1433-7851

VL - 51

SP - 7952

EP - 7955

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 32

ER -