Solution-phase synthesis of a 1,5-dialkylamino-2,4-dinitrobenzene library and the identification of novel antibacterial compounds from this library

Gang Liu, Yemei Fan, James R. Carlson, Zhan Gong Zhao, Kit S. Lam

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Abstract

In this report we demonstrate that a 1,5-dialkylamino-2,4-dinitrobenzene small molecule library can be generated by a highly efficient solution-phase synthesis method. From this 2485-member library, a series of novel compounds with antibacterial activity were isolated. The significance of this report is that the synthetic scheme is extremely simple, with minimal number of liquid handling steps, and the solvents and reagents left in the final library preparation are fully compatible with cell-based assays.

Original languageEnglish (US)
Pages (from-to)467-474
Number of pages8
JournalJournal of Combinatorial Chemistry
Volume2
Issue number5
DOIs
StatePublished - Jan 1 2000

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ASJC Scopus subject areas

  • Chemistry(all)

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