Solution-phase secondary-ion mass spectrometry of protonated amino acids

George Pettit; Gordon M. Cragg; Cedric W. Holzapfel; Albert A. Tuinman; Donald P. Gieschen

doi:10.1016/0003-2697(87)90032-7

Solution-phase secondary-ion mass spectrometry of protonated amino acids

George Pettit, Gordon M. Cragg, Cedric W. Holzapfel, Albert A. Tuinman, Donald P. Gieschen

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

Although sulfolane proved unexpectedly to be a poor solvent for solution-phase secondaryion mass spectrometry of underivatized amino acids in the presence of thallium(I) salts, glycerol was somewhat more effective. Also, the addition of trifluoromethanesulfonic acid proved more effective than addition of the metal in generating molecular ion complexes. A convenient and reliable method for rapidly determining amino acid molecular ions is based on these observations.

Original language	English (US)
Pages (from-to)	236-241
Number of pages	6
Journal	Analytical Biochemistry
Volume	162
Issue number	1
DOIs	https://doi.org/10.1016/0003-2697(87)90032-7
State	Published - Apr 1987

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Keywords

amino acids
mass spectrometry

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Cite this

Pettit, G., Cragg, G. M., Holzapfel, C. W., Tuinman, A. A., & Gieschen, D. P. (1987). Solution-phase secondary-ion mass spectrometry of protonated amino acids. Analytical Biochemistry, 162(1), 236-241. https://doi.org/10.1016/0003-2697(87)90032-7

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10.1016/0003-2697(87)90032-7