Abstract
Although sulfolane proved unexpectedly to be a poor solvent for solution-phase secondaryion mass spectrometry of underivatized amino acids in the presence of thallium(I) salts, glycerol was somewhat more effective. Also, the addition of trifluoromethanesulfonic acid proved more effective than addition of the metal in generating molecular ion complexes. A convenient and reliable method for rapidly determining amino acid molecular ions is based on these observations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 236-241 |
| Number of pages | 6 |
| Journal | Analytical Biochemistry |
| Volume | 162 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1987 |
Keywords
- amino acids
- mass spectrometry
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Cite this
Pettit, G., Cragg, G. M., Holzapfel, C. W., Tuinman, A. A., & Gieschen, D. P. (1987). Solution-phase secondary-ion mass spectrometry of protonated amino acids. Analytical Biochemistry, 162(1), 236-241. https://doi.org/10.1016/0003-2697(87)90032-7