Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A5

Christopher J. Leitheiser, Michael J. Rishel, Xihan Wu, Sidney M. Hecht

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

(matrix presented) The solid-phase syntheses of two deglycobleomycin A5 analogues were achieved using a commercially available polystyrene resin containing triphenylmethyl-linked spermidine. The final products were deblocked and released from the resin, analyzed, and purified by C18 reversed phase HPLC and characterized by high-field 1H NMR spectroscopy and mass spectrometry. The purified products relaxed supercoiled plasmid DNA in a concentration-dependent fashion and to the same extent as authentic material derived from natural BLM A5.

Original languageEnglish (US)
Pages (from-to)3397-3399
Number of pages3
JournalOrganic Letters
Volume2
Issue number21
DOIs
StatePublished - Oct 19 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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